FLUCYBENE

• CAT Number: T000116
• CAS Number: 3289-22-3
• Molecular Formula: C11H6F6N2
• Purity: ≥95%
• Solubility: In alcohol, alcohol + water and acetone.
• Storage: Store at room temperature. 1 mg Cloflubicyne can be dissolved in 1 ml ethanol (up to 50 °C), then diluted in distilled water. Solution for experiments must contain less than 0.5 % ethanol and be stored at 0 °C.

FLUCYBENE(cas 3289-22-3) is a potent non-competitive GABA antagonist in mammalian, molluscan and insects, a convulsant and a laboratory insecticide.

Organofluorate compound, synthetic
(IC50) for blocking the GABA-dependent [36Cl] uptake in rat brain synaptosomes: 50 nM; Inhibition of the GABA-dependent Cl- current at 61.0 nM;Experiments with [3H]-labelled GABA-competitive ligands (muscimol, GABA) showed no influence of Flucybene up to 10 μM.

Reference

– Middelton et al., J. Fluor. Chem.(1982) 20:397-418

– Fetisov et al., J. Fluor. Chem.(1991) 54:301