BRD-73954

• CAT Number: I001697
• CAS Number: 1440209-96-0
• Molecular Formula: C₁₆H₁₆N₂O₃
• Molecular Weight: 284.31
• Purity: ≥95%
• Synonyms: N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide
• Target: HDAC
• Solubility: DMSO: ≥ 35 mg/mL
• Storage: -20°C
• IC50: 36 nM (HDAC6), 120 nM (HDAC8)
• InChI: InChI=1S/C16H16N2O3/c19-15(17-10-9-12-5-2-1-3-6-12)13-7-4-8-14(11-13)16(20)18-21/h1-8,11,21H,9-10H2,(H,17,19)(H,18,20)
• InChIKey: FIHKWEQJEDRIFS-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)CCNC(=O)C2=CC(=CC=C2)C(=O)NO

BRD-73954 (CAT: I001697) is a potent and selective inhibitor of histone deacetylases (HDACs). HDACs are enzymes that regulate gene expression by removing acetyl groups from histone proteins, leading to chromatin condensation and gene silencing. By inhibiting HDACs, BRD-73954 can promote histone acetylation, resulting in altered gene expression patterns and potential therapeutic effects.

Reference

[1]. Olson DE, et al. Discovery of the first histone deacetylase 6/8 dual inhibitors. J Med Chem. 2013 Jun 13;56(11):4816-4820.