BRD-6929

• CAT Number: I018302
• CAS Number: 849234-64-6
• Molecular Formula: C₁₉H₁₇N₃O₂S
• Molecular Weight: 351.42
• Purity: ≥95%
• IUPAC Name: 4-acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamide
• InChI: InChI=1S/C19H17N3O2S/c1-12(23)21-15-7-4-13(5-8-15)19(24)22-17-11-14(6-9-16(17)20)18-3-2-10-25-18/h2-11H,20H2,1H3,(H,21,23)(H,22,24)
• InChIKey: ABZSPJVXTTUFAA-UHFFFAOYSA-N
• SMILES: CC(=O)NC1=CC=C(C=C1)C(=O)NC2=C(C=CC(=C2)C3=CC=CS3)N

BRD 6929 (Cat.No:I018302) is a selective, brain-penetrant inhibitor of class I histone deacetylases (HDACs), with an IC50 of 1 and 8 nM for HDAC1 and HDAC2, respectively. It has high affinity for HDAC1 and HDAC2 with Ki values of 0.2 and 1.5 nM, respectively. BRD 6929 can be used in the study of emotion-related behavior and has shown efficacy in potentiating the activity of aPKC agonist against latent HIV-1.

Reference

[1]. Li-Huei Tsai, et al. Inhibition of hdac2 to promote memory. patent/US20120101147[2]. Schroeder FA, et al. A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and altersmouse behavior in two mood-related tests. PLoS One. 2013 Aug 14;8(8):e71323.[3]. Huang L, et al. Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor. ACS Med Chem Lett. 2018 Feb 6;9(3):268-273.