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BML210

BML210

  • CAT Number: I003960
  • CAS Number: 537034-17-6
  • Molecular Formula: C₂₀H₂₅N₃O₂
  • Molecular Weight: 339.43
  • Purity: ≥95%
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<p style=/line-height:25px/>BML-210 is the novel HDAC inhibitor, and its mechanism of action has not been characterized.<br>IC50 value: 5 μM [1]<br>Target: HDAC4<br>In vitro: Cell cycle analysis indicated that HeLa cell treatment with<br>20 and 30 μM concentration of BML-210 increased the<br>proportion of cells in G0/G1 phase, and caused accumulation<br>in subG1, indicating that the cells are undergoing apoptosis [2]. BML-210 inhibits the growth of NB4 cells in dose- and time-dependent manner [3].<br>In vivo:<br></p>

Catalog Number I003960
CAS Number 537034-17-6
Molecular Formula

C₂₀H₂₅N₃O₂

Purity 95%
Target HDAC4
Solubility DMSO: ≥ 30 mg/mL
Storage -20°C
IC50 5 μM [1]
InChI InChI=1S/C20H25N3O2/c21-17-12-8-9-13-18(17)23-20(25)15-7-2-1-6-14-19(24)22-16-10-4-3-5-11-16/h3-5,8-13H,1-2,6-7,14-15,21H2,(H,22,24)(H,23,25)
InChIKey RFLHBLWLFUFFDZ-UHFFFAOYSA-N
SMILES C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NC2=CC=CC=C2N
Reference

</br>1:The Histone Deacetylase Inhibitor BML-210 Influences Gene and Protein Expression in Human Promyelocytic Leukemia NB4 Cells via Epigenetic Reprogramming. Borutinskaitė V, Navakauskienė R.Int J Mol Sci. 2015 Aug 6;16(8):18252-69. doi: 10.3390/ijms160818252. PMID: 26287160 Free PMC Article</br>2:Histone deacetylase inhibitor BML-210 induces growth inhibition and apoptosis and regulates HDAC and DAPC complex expression levels in cervical cancer cells. Borutinskaite VV, Magnusson KE, Navakauskiene R.Mol Biol Rep. 2012 Dec;39(12):10179-86. doi: 10.1007/s11033-012-1892-5. Epub 2012 Sep 26. PMID: 23007576 </br>3:Retinoic acid and histone deacetylase inhibitor BML-210 inhibit proliferation of human cervical cancer HeLa cells. Borutinskaite VV, Navakauskiene R, Magnusson KE.Ann N Y Acad Sci. 2006 Dec;1091:346-55. PMID: 17341627 </br>4:The novel histone deacetylase inhibitor BML-210 exerts growth inhibitory, proapoptotic and differentiation stimulating effects on the human leukemia cell lines. Savickiene J, Borutinskaite VV, Treigyte G, Magnusson KE, Navakauskiene R.Eur J Pharmacol. 2006 Nov 7;549(1-3):9-18. Epub 2006 Aug 15. PMID: 16978604

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