BG-45

• CAT Number: I005513
• CAS Number: 926259-99-6
• Molecular Formula: C₁₁H₁₀N₄O
• Molecular Weight: 214.23
• Purity: ≥95%
• Target: HDAC
• Solubility: DMSO: ≥ 48 mg/mL
• Storage: 2-8°C
• IC50: 289 nM (HDAC3), 2 μM (HDAC1), 2.2 μM (HDAC2), >20 μM (HDAC6)
• IUPAC Name: N-(2-aminophenyl)pyrazine-2-carboxamide
• InChI: InChI=1S/C11H10N4O/c12-8-3-1-2-4-9(8)15-11(16)10-7-13-5-6-14-10/h1-7H,12H2,(H,15,16)
• InChIKey: LMWPVSNHKACEKW-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)N)NC(=O)C2=NC=CN=C2

BG45（Cat No.:I005513） is a selective inhibitor of histone deacetylase class I, specifically targeting HDAC3 with an IC50 value of 289 nM. It also exhibits inhibitory activity against HDAC1, HDAC2, and HDAC6, albeit with reduced potency (IC50s of 2 μM, 2.2 μM, and >20 μM, respectively). In preclinical studies using a mouse model of multiple myeloma, BG45 demonstrated dose-dependent inhibition of tumor growth when administered alone or in combination with the drug Bortezomib.

Reference

[1]. Iaconelli J, et al. HDAC6 Inhibitors Modulate Lys49 Acetylation and Membrane Localization of β-Catenin in Human iPSC-Derived Neuronal Cells. ACS Chemical Biology (2015), 10(3), 883-890.