AS 602801

• CAT Number: I005085
• CAS Number: 848344-36-5
• Molecular Formula: C₂₅H₂₃N₅O₂S
• Molecular Weight: 457.55
• Purity: ≥95%
• Target: JNK
• Solubility: DMSO：10.8 mg/mL
• Storage: Store at -20°C
• InChI: InChI=1S/C25H23N5O2S/c26-15-20(24-28-22-3-1-2-4-23(22)33-24)21-9-10-27-25(29-21)32-17-19-7-5-18(6-8-19)16-30-11-13-31-14-12-30/h1-10,20H,11-14,16-17H2
• InChIKey: XCPPIJCBCWUBNT-UHFFFAOYSA-N
• SMILES: C1COCCN1CC2=CC=C(C=C2)COC3=NC=CC(=N3)C(C#N)C4=NC5=CC=CC=C5S4

AS 602801(Bentamapimod) is a novel, orally active inhibitor of JNK.IC50 value:Target: JNKIn activated PBMCs from HVs, we showed that AS602801 blocked T-lymphocyte proliferation and induced apoptosis. In RRMS CD4+ and CD8+ cells, AS602801 induced apoptosis genes and expression of surface markers, while in RRMS CD11b+ cells it induced expression of innate immunity receptors and co-stimulatory molecules. Untreated cells from RRMS active-phase patients significantly released interleukin-23 (IL-23) and interferon-gamma (IFN-γ) and expressed less apoptosis markers compared to the cells of HVs.

Reference

[1]. Ferrandi C, Richard F, Tavano P, Hauben E, Barbié V, Gotteland JP, Greco B, Fortunato M, Mariani MF, Furlan R, Comi G, Martino G, Zaratin PF. Characterization of immune cell subsets during the active phase of multiple sclerosis reveals disease and c-Jun N-terminal kinase pathway biomarkers. Mult Scler. 2011 Jan;17(1):43-56.