Aminoacyl tRNA synthetase-IN-1

• CAT Number: I013003
• CAS Number: 219931-45-0
• Molecular Formula: C₁₆H₂₅N₇O₇S
• Molecular Weight: 459.48
• Purity: ≥95%
• Target: Bacterial
• Solubility: DMSO
• IUPAC Name: [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl N-[(2S,3S)-2-amino-3-methylpentanoyl]sulfamate
• InChI: InChI=1S/C16H25N7O7S/c1-3-7(2)9(17)15(26)22-31(27,28)29-4-8-11(24)12(25)16(30-8)23-6-21-10-13(18)19-5-20-14(10)23/h5-9,11-12,16,24-25H,3-4,17H2,1-2H3,(H,22,26)(H2,18,19,20)/t7-,8+,9-,11+,12+,16+/m0/s1
• InChIKey: ADKZHDGLJXVNIT-VBJYJYTRSA-N
• SMILES: CCC(C)C(C(=O)NS(=O)(=O)OCC1C(C(C(O1)N2C=NC3=C2N=CN=C3N)O)O)N

Aminoacyl tRNA synthetase-IN-1（Cat No.:I013003） is a small molecule inhibitor that targets aminoacyl tRNA synthetase (aaRS) in bacteria. By disrupting the function of aaRS, the drug inhibits bacterial protein synthesis and growth, making it a potential antimicrobial agent. Aminoacyl tRNA synthetase-IN-1 has shown efficacy against a broad range of bacterial species, including drug-resistant strains, and has the potential to be used in combination with other antibiotics to enhance their efficacy.

Reference

[1]. Vondenhoff GH, et al. Microcin C and albomycin analogues with aryl-tetrazole substituents as nucleobase isosters areselective inhibitors of bacterial aminoacyl tRNA synthetases but lack efficient uptake. Chembiochem. 2012 Sep 3;13(13):1959-69.