Clofazimine is a fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. Clofazimine works by binding to the guanine bases of bacterial DNA, thereby blocking the template function of the DNA and inhibiting bacterial proliferation.
Catalog Number | A000925 |
CAS Number | 2030-63-9 |
Synonyms | 2030-63-9; Lamprene; Lampren; Chlofazimine; Clofazimina |
Molecular Formula | C27H22Cl2N4 |
Purity | ≥95% |
Storage | -20°C |
InChI | 1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3 |
InChIKey | WDQPAMHFFCXSNU-BGABXYSRSA-N |
SMILES | CC(C)N=C1C=C2C(=NC3=CC=CC=C3N2C4=CC=C(C=C4)Cl)C=C1NC5=CC=C(C=C5)Cl |
Reference | 1: Lin J, Lin Z, Li D, Feng M, Yang Q, Hu W, Han Y, Zhu W, Li M, Yu L. /Ghost 2: Maartens G, Brill MJE, Pandie M, Svensson EM. Pharmacokinetic interaction <br> 4: Yew WW, Liang D, Chan DP, Shi W, Zhang Y. Molecular mechanisms of clofazimine 5: Tuvshintulga B, AbouLaila M, Sivakumar T, Tayebwa DS, Gantuya S, Naranbaatar 6: Brunaugh AD, Jan SU, Ferrati S, Smyth HDC. Excipient-Free Pulmonary Delivery 7: Murashov MD, LaLone V, Rzeczycki PM, Keswani RK, Yoon GS, Sud S, Rajeswaran W, 8: Xu J, Tasneen R, Peloquin CA, Almeida DV, Li SY, Barnes-Boyle K, Lu Y, 9: Sangana R, Gu H, Chun DY, Einolf HJ. Evaluation of Clinical Drug Interaction 10: Makgatho EM, Mbajiorgu EF. In vitro investigation of clofazimine analogues |