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AES-350

AES-350

  • CAT Number: I021446
  • CAS Number: 847249-57-4
  • Molecular Formula: C18H20N2O3
  • Molecular Weight: 312.36
  • Purity: 98%
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AES-350 (Cat.No:I021446) is a potent and selective HDAC6 inhibitor. AES-350 demonstrated greater HDAC isoform selectivity, higher cytotoxicity in MV4-11 cells, an improved therapeutic window, and more efficient absorption through cellular and lipid membranes. AES-350 also demonstrated improved oral bioavailability compared to SAHA in mouse models. AES-350 exhibited an in vitro HDAC6 selectivity profile comparable to that of ricolinostat and citarinostat.

Catalog Number I021446
CAS Number 847249-57-4
Synonyms

AES-350; AES 350; AES350;

Molecular Formula

C18H20N2O3

Purity 98
Solubility Soluble in DMSO
Storage Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
IUPAC Name 4-(tert-butyl)-N-(4-(hydroxycarbamoyl)phenyl)benzamide
InChI InChI=1S/C18H20N2O3/c1-18(2,3)14-8-4-12(5-9-14)16(21)19-15-10-6-13(7-11-15)17(22)20-23/h4-11,23H,1-3H3,(H,19,21)(H,20,22)
InChIKey FMOQHLZNJFXULZ-UHFFFAOYSA-N
SMILES CC(C)(C)C1=CC=C(C(NC2=CC=C(C(NO)=O)C=C2)=O)C=C1

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