Achn-975 trifluoroacetate

• CAT Number: I006143
• CAS Number: 1410809-37-8
• PubChem Substance ID: 118237053
• Molecular Formula: C22H24F3N3O6
• Molecular Weight: 483.4
• Purity: ≥95%
• IUPAC Name: N-[(2S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-4-[4-[(1R,2R)-2-(hydroxymethyl)cyclopropyl]buta-1,3-diynyl]benzamide;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C20H23N3O4.C2HF3O2/c1-20(2,21)17(19(26)23-27)22-18(25)14-9-7-13(8-10-14)5-3-4-6-15-11-16(15)12-24;3-2(4,5)1(6)7/h7-10,15-17,24,27H,11-12,21H2,1-2H3,(H,22,25)(H,23,26);(H,6,7)/t15-,16+,17-;/m1./s1
• InChIKey: JDWOCPXDDCJBBA-UNLWNTODSA-N
• SMILES: CC(C)(C(C(=O)NO)NC(=O)C1=CC=C(C=C1)C#CC#CC2CC2CO)N.C(=O)(C(F)(F)F)O

ACHN-975 trifluoroacetate (CAT: I006143) is a selective inhibitor of the enzyme LpxC, which is involved in the biosynthesis of lipid A, an essential component of the outer membrane of Gram-negative bacteria. By inhibiting LpxC, ACHN-975 can disrupt bacterial membrane integrity and lead to bacterial death. It has been studied for its potential antibacterial properties, particularly against multidrug-resistant Gram-negative bacteria, which are becoming increasingly common and difficult to treat with existing antibiotics. ACHN-975 is being developed as a potential therapeutic agent for various bacterial infections, including urinary tract infections, pneumonia, and sepsis.