Desmopressin Acetate


CAS No. : 62288-83-9

Desmopressin Acetate,62288-83-9
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:P000412
Synonyms:DDAVP
Molecular Formula:C48H68N14O14S2
Molecular Weight:1129.27
Target:Vasopressin Receptor
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Inventory Status:In Stock
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Purity:98%(HPLC)
Cat No:P000412
Cas No:62288-83-9
Product-Name:Desmopressin Acetate
IUPAC Name:acetic acid;N-[1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
InChI:InChI=1S/C46H64N14O12S2.C2H4O2/c47-35(62)15-14-29-40(67)58-32(22-36(48)63)43(70)59-33(45(72)60-18-5-9-34(60)44(71)56-28(8-4-17-52-46(50)51)39(66)53-23-37(49)64)24-74-73-19-16-38(65)54-30(21-26-10-12-27(61)13-11-26)41(68)57-31(42(69)55-29)20-25-6-2-1-3-7-25;1-2(3)4/h1-3,6-7,10-13,28-34,61H,4-5,8-9,14-24H2,(H2,47,62)(H2,48,63)(H2,49,64)(H,53,66)(H,54,65)(H,55,69)(H,56,71)(H,57,68)(H,58,67)(H,59,70)(H4,50,51,52);1H3,(H,3,4)
InChIKey:MLSVJHOYXJGGTR-UHFFFAOYSA-N
SMILES:CC(=O)O.C1CC(N(C1)C(=O)C2CSSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC (C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C (C=C4)O)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N

Desmopressin(DDAVP) acetate(cas 62288-83-9) is the synthetic analogue of the antidiuretic hormone arginine vasopressin. Desmopressin acetate has selective affinity for the V2 receptor and acts on the distal kidney tubule by increasing the cellular permeability thereby stimulating water reabsorption. This antidiuretic agent is used in the treatment of central diabetes insipidus. An unrelated action of desmopressin acetate is to increases circulating factor VIII and is used in patients with haemophilia and von Willebrand/'s disease.

1. Haemostasis. 1992;22(5):276-80.

Desmopressin: a nontransfusional treatment of hemophilia and von Willebrand disease.

Mannucci PM(1), Cattaneo M.
Author information:
(1)Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Ospedale Maggiore, Milano, Italy.

Desmopressin (1-deamino-8-D-arginine vasopressin) is a synthetic analogue of the antidiuretic hormone L-arginine vasopressin. Because it can raise circulating levels of factor VIII and von Willebrand factor, desmopressin is used for nontransfusional treatment of mild and moderate hemophilia and von Willebrand disease. Desmopressin also shortens the prolonged skin bleeding time in patients suffering from von Willebrand disease and is given to prevent or stop excessive bleeding in such conditions.

2. Am Fam Physician. 1990 Oct;42(4):1051-7.

Desmopressin for diabetes insipidus, hemostatic disorders and enuresis.

Shulman LH(1), Miller JL, Rose LI.
Author information:
(1)Division of Endocrinology-Metabolism, Hahnemann University School of Medicine, Philadelphia, Pennsylvania.
Arginine vasopressin preparations have been used in the treatment of diabetes insipidus for many years. Compared with older antidiuretic agents, the synthetic analog desmopressin is more potent, longer acting and easier to use. It is available for intravenous, subcutaneous and intranasal administration. Desmopressin may be useful in the treatment of hemostatic disorders such as von Willebrand/'s disease and hemophilia A. It has also been used for nocturnal enuresis. The vasopressor effects of arginine vasopressin preparations have been exploited for use as a temporizing measure in controlling acute gastrointestinal bleeding. Side effects such as hyponatremia and water intoxication are uncommon when these drugs are used with proper precautions.
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