Desmopressin Acetate

• CAT Number: P000412
• CAS Number: 62288-83-9
• Molecular Formula: C48H68N14O14S2
• Molecular Weight: 1129.27
• Purity: 98%
• Target: Vasopressin Receptor
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• Analysis method: HPLC
• IUPAC Name: acetic acid;N-[1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
• InChI: InChI=1S/C46H64N14O12S2.C2H4O2/c47-35(62)15-14-29-40(67)58-32(22-36(48)63)43(70)59-33(45(72)60-18-5-9-34(60)44(71)56-28(8-4-17-52-46(50)51)39(66)53-23-37(49)64)24-74-73-19-16-38(65)54-30(21-26-10-12-27(61)13-11-26)41(68)57-31(42(69)55-29)20-25-6-2-1-3-7-25;1-2(3)4/h1-3,6-7,10-13,28-34,61H,4-5,8-9,14-24H2,(H2,47,62)(H2,48,63)(H2,49,64)(H,53,66)(H,54,65)(H,55,69)(H,56,71)(H,57,68)(H,58,67)(H,59,70)(H4,50,51,52);1H3,(H,3,4)
• InChIKey: MLSVJHOYXJGGTR-UHFFFAOYSA-N
• SMILES: CC(=O)O.C1CC(N(C1)C(=O)C2CSSCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC (C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C (C=C4)O)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)N

Desmopressin Acquire (CAT: P000412) is also called DDAVP. Desmopressin is a synthetic octapeptide, which is an analog of arginine vasopressin, a human hormone, and has antidiuretic and procoagulant effects. It can be used to treat central diabetes insipidus and nocturnal enuresis of patients aged 6 years or above. This product is used in medical research and development and other scientific research fields.

Reference

1. Haemostasis. 1992;22(5):276-80.
Desmopressin: a nontransfusional treatment of hemophilia and von Willebrand disease.
Mannucci PM(1), Cattaneo M.
Author information:
(1)Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Ospedale Maggiore, Milano, Italy.
Desmopressin (1-deamino-8-D-arginine vasopressin) is a synthetic analogue of the antidiuretic hormone L-arginine vasopressin. Because it can raise circulating levels of factor VIII and von Willebrand factor, desmopressin is used for nontransfusional treatment of mild and moderate hemophilia and von Willebrand disease. Desmopressin also shortens the prolonged skin bleeding time in patients suffering from von Willebrand disease and is given to prevent or stop excessive bleeding in such conditions.

2. Am Fam Physician. 1990 Oct;42(4):1051-7.
Desmopressin for diabetes insipidus, hemostatic disorders and enuresis.
Shulman LH(1), Miller JL, Rose LI.
Author information:
(1)Division of Endocrinology-Metabolism, Hahnemann University School of Medicine, Philadelphia, Pennsylvania.
Arginine vasopressin preparations have been used in the treatment of diabetes insipidus for many years. Compared with older antidiuretic agents, the synthetic analog desmopressin is more potent, longer acting and easier to use. It is available for intravenous, subcutaneous and intranasal administration. Desmopressin may be useful in the treatment of hemostatic disorders such as von Willebrand/'s disease and hemophilia A. It has also been used for nocturnal enuresis. The vasopressor effects of arginine vasopressin preparations have been exploited for use as a temporizing measure in controlling acute gastrointestinal bleeding. Side effects such as hyponatremia and water intoxication are uncommon when these drugs are used with proper precautions.