ophiobolin C


CAS No. : 19022-51-6

ophiobolin C,19022-51-6
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:M082949
Synonyms:(1R,3aS,6aS,7R,9aR,10aS)-7-[(1S)-1,5-dimethyl-4-hexen-1-yl]-1,2,3,3a,6,6a,7,8,9,9a,10,10a-dodecahydro-1-hydroxy-1,9a-dimethyl-3-oxo-dicyclopenta[a,d]cyclooctene-4-carboxaldehyde
Molecular Formula:C25H38O3
Molecular Weight:386.6
Target:CCR5
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Appearance:White solid
Cat No:M082949
Cas No:19022-51-6
Product-Name:ophiobolin C
InChIKey:PLWMYIADTRHIMY-BNFAVABNSA-N
Ophiobolin C is a member of the ophiobolin class of phytotoxic metabolites produced by many species of the genus Bipolaris.
Ophiobolin C inhibits human CCR5 binding to the envelope protein gp120 and CD4 that mediates HIV-1 entry into cells. Blockade of this binding was considered by scientists at Merck as a potential new mode of action for the treatment of HIV-1 infection.
The structure of zizannin-A and -B, C25-terpenoids isolated from Helminthosporium zizaniae. Nozoe S. et al. , Tetrahedron Lett. 1966, 7, 2211.

Isolation and structure of antagonists of chemokine receptor (CCR5). Jayasuriya et al. , H. J. Nat. Prod. 2004, 67, 1036.

The biology of ophiobolins. Au T.K. et al. , Life Sci. 2000, 67, 733. (Review).

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