CAS No. : 362519-49-1

Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I013658
Molecular Formula:C₂₃H₂₀Cl₂N₄O₂S
Molecular Weight:487.4
Target: Cannabinoid Receptor
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Cat No:I013658
Cas No:362519-49-1
IUPAC Name:5-(4-chlorophenyl)-N-(4-chlorophenyl)sulfonyl-N//'-methyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
(±)-SLV319 is the racemate of SLV319. SLV319 is a potent and selective cannabinoid-1 (CB-1) receptor antagonist with an IC50 of 22 nM.
[1]. Chorvat RJ, et al. JD-5006 and JD-5037: peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6173-80.
[2]. Lange JH, et al. Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists. J Med Chem. 2004 Jan 29;47(3):627-43.
[3]. Rohrbach K, et al. Ibipinabant attenuates β-cell loss in male Zucker diabetic fatty rats independently of its effects on body weight. Diabetes Obes Metab. 2012 Jun;14(6):555-64.
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