((plusmn))-SLV319


CAS No. : 362519-49-1

((plusmn))-SLV319,362519-49-1
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I013658
Molecular Formula:C₂₃H₂₀Cl₂N₄O₂S
Molecular Weight:487.4
Target: Cannabinoid Receptor
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Cat No:I013658
Cas No:362519-49-1
Product-Name:((plusmn))-SLV319
IUPAC Name:5-(4-chlorophenyl)-N-(4-chlorophenyl)sulfonyl-N//'-methyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
InChI:InChI=1S/C23H20Cl2N4O2S/c1-26-23(28-32(30,31)20-13-11-19(25)12-14-20)29-15-21(16-5-3-2-4-6-16)22(27-29)17-7-9-18(24)10-8-17/h2-14,21H,15H2,1H3,(H,26,28)
InChIKey:AXJQVVLKUYCICH-UHFFFAOYSA-N
SMILES:CN=C(NS(=O)(=O)C1=CC=C(C=C1)Cl)N2CC(C(=N2)C3=CC=C(C=C3)Cl)C4=CC=CC=C4
(±)-SLV319 is the racemate of SLV319. SLV319 is a potent and selective cannabinoid-1 (CB-1) receptor antagonist with an IC50 of 22 nM.
[1]. Chorvat RJ, et al. JD-5006 and JD-5037: peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6173-80.
[2]. Lange JH, et al. Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists. J Med Chem. 2004 Jan 29;47(3):627-43.
[3]. Rohrbach K, et al. Ibipinabant attenuates β-cell loss in male Zucker diabetic fatty rats independently of its effects on body weight. Diabetes Obes Metab. 2012 Jun;14(6):555-64.
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