((plusmn))-SLV319

• CAT Number: I013658
• CAS Number: 362519-49-1
• Molecular Formula: C₂₃H₂₀Cl₂N₄O₂S
• Molecular Weight: 487.4
• Purity: ≥95%
• Target: Cannabinoid Receptor
• Solubility: DMSO: ≥ 31 mg/mL
• IUPAC Name: 5-(4-chlorophenyl)-N-(4-chlorophenyl)sulfonyl-N//'-methyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
• InChI: InChI=1S/C23H20Cl2N4O2S/c1-26-23(28-32(30,31)20-13-11-19(25)12-14-20)29-15-21(16-5-3-2-4-6-16)22(27-29)17-7-9-18(24)10-8-17/h2-14,21H,15H2,1H3,(H,26,28)
• InChIKey: AXJQVVLKUYCICH-UHFFFAOYSA-N
• SMILES: CN=C(NS(=O)(=O)C1=CC=C(C=C1)Cl)N2CC(C(=N2)C3=CC=C(C=C3)Cl)C4=CC=CC=C4

(±)-SLV319 is the racemate of SLV319. SLV319 is a potent and selective cannabinoid-1 (CB-1) receptor antagonist with an IC50 of 22 nM.

Reference

[1]. Chorvat RJ, et al. JD-5006 and JD-5037: peripherally restricted (PR) cannabinoid-1 receptor blockers related to SLV-319 (Ibipinabant) as metabolic disorder therapeutics devoid of CNS liabilities. Bioorg Med Chem Lett. 2012 Oct 1;22(19):6173-80. [2]. Lange JH, et al. Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists. J Med Chem. 2004 Jan 29;47(3):627-43.[3]. Rohrbach K, et al. Ibipinabant attenuates β-cell loss in male Zucker diabetic fatty rats independently of its effects on body weight. Diabetes Obes Metab. 2012 Jun;14(6):555-64.