HT-2157


CAS No. : 303149-14-6

HT-2157,303149-14-6
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I003060
Synonyms:SNAP 3788; SNAP3788; HT2157
Molecular Formula:C21H13F3N2O
Molecular Weight:366.34
Target:Galanin-3 receptor
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Inventory Status:In stock!
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Appearance:Solid powder
Purity: > 98%
Cat No:I003060
Cas No:303149-14-6
Product-Name:HT-2157
InChI:InChI=1S/C21H13F3N2O/c22-21(23,24)14-7-6-8-15(13-14)25-19-17-11-4-5-12-18(17)26(20(19)27)16-9-2-1-3-10-16/h1-13H/b25-19-
InChIKey:TXCGMRVPXUBHAL-PLRJNAJWSA-N
SMILES:O=C1N(C2=CC=CC=C2)C3=C(C=CC=C3)/C1=N/C4=CC=CC(C(F)(F)F)=C4

HT-2157(cas 303149-14-6), also known as SNAP 37889, is a selective, high-affinity, competitive antagonists of galanin-3 receptor (Gal3). HT-2157(SNAP 37889)binds with high affinity to membranes from transiently transfected LMTK- cells expressing the human Gal3 receptor (Ki=17.44±0.01 nM; n>100) and is highly selective for Gal3 over the Gal1 and Gal2 subtypes (Ki>10,000 nM for each subtype; n=46 of each subtype). When tested for the antagonism of galanin-evoked inhibition of adenylyl cyclase, HT-2157 (0.1-10 μM) produces concentration-dependent rightward shifts of the concentration-effect curve to galanin.
InVivo: The galanin-3 receptor antagonist, HT-2157(SNAP 37889), reduces operant responding for ethanol in alcohol-preferring rats. The novel selective GALR3 antagonist, HT-2157, to reduce anxiety-like behaviour and voluntary ethanol consumption in the iP (alcohol-preferring) rat. Male iP rats treated with HT-2157 at a dose of 30 mg/kg (i.p.) do not show altered locomotor activity or changes in anxiety-like behaviour in the elevated plus maze or light-dark paradigms. Treatment with HT-2157 (30 mg/kg, i.p.) reduces operant responding for solutions containing ethanol, sucrose and saccharin. Collectively, results from the current study shows that HT-2157 (30 mg/kg, i.p.) is effective in reducing operant responding for ethanol, independent of a sedative effect.


[1]. Swanson CJ, et al. Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17489-94.
[2]. Ash BL, et al. The galanin-3 receptor antagonist, SNAP 37889, reduces operant responding for ethanol in alcohol-preferring rats. Regul Pept. 2011 Jan 17;166(1-3):59-67.

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