HT-2157

• CAT Number: I003060
• CAS Number: 303149-14-6
• Molecular Formula: C21H13F3N2O
• Molecular Weight: 366.34
• Purity: ≥95%
• Target: Galanin-3 receptor
• Solubility: DMSO: ≥ 29 mg/mL
• Storage: Store at +4C
• InChI: InChI=1S/C21H13F3N2O/c22-21(23,24)14-7-6-8-15(13-14)25-19-17-11-4-5-12-18(17)26(20(19)27)16-9-2-1-3-10-16/h1-13H/b25-19-
• InChIKey: TXCGMRVPXUBHAL-PLRJNAJWSA-N
• SMILES: O=C1N(C2=CC=CC=C2)C3=C(C=CC=C3)/C1=N/C4=CC=CC(C(F)(F)F)=C4

HT-2157 (CAT: I003060), also known as SNAP 37889, is a selective and high-affinity competitive antagonist of the galanin-3 receptor (Gal3). It has been shown to bind with high affinity to membranes expressing the human Gal3 receptor, exhibiting a Ki value of 17.44 ± 0.01 nM. HT-2157 is highly selective for Gal3 over the Gal1 and Gal2 receptor subtypes, with Ki values greater than 10,000 nM for each subtype. In functional assays, HT-2157 has demonstrated concentration-dependent antagonism of galanin-induced inhibition of adenylyl cyclase.

Reference

[1]. Swanson CJ, et al. Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17489-94.
[2]. Ash BL, et al. The galanin-3 receptor antagonist, SNAP 37889, reduces operant responding for ethanol in alcohol-preferring rats. Regul Pept. 2011 Jan 17;166(1-3):59-67.