|IUPAC Name:||3-acetamido-2,4,6-triiodo-5-(methylcarbamoyl)benzoic acid|
Iothalamic Acid(CAS: 2276-90-6) is an ionic tri-iodinated benzoate used as a contrast agent in diagnostic imaging. Like other organic iodine compounds, iothalamic acid blocks x-ray and appears opaque on x-ray film, thereby enhancing the visibility of structure and organs during angiography, arteriography, arthrography, cholangiography, and computed tomography (CT) scanning procedures.
. Ann Pharm Fr. 1972 Jun;30(6):473-6.
[Article in French]
[No authors listed]
PMID: 4638742 [Indexed for MEDLINE]
. J Pharm Sci. 1963 Dec;52:1180-2.
QUALITATIVE AND QUANTITATIVE TESTS FOR IOTHALAMIC ACID.
PMID: 14088971 [Indexed for MEDLINE]
. J Chromatogr. 1991 Oct 4;570(2):435-40. doi: 10.1016/0378-4347(91)80550-v.
High-performance liquid chromatographic determination of iothalamic acid in human plasma and urine.
Gaspari F(1), Mainardi L, Ruggenenti P, Remuzzi G.
Author information: (1)Mario Negri Institute for Pharmacological Research, Laboratory of Clinical Pharmacokinetics, Bergamo, Italy.
A simple, rapid and sensitive method for the determination of iothalamic acid (IA) in both plasma and urine is reported. After extraction with ethyl acetate, IA was determined by strong anion-exchange high-performance liquid chromatography with ultraviolet detection at 254 nm. The lower limit of detection was 0.5 micrograms/ml. The average recovery was 73 and 57% from plasma and urine, respectively. Linearity was found over the investigated concentration range (up to 500 micrograms/ml for plasma and up to 10.0 mg/ml for urine). The reproducibility of the technique was good (coefficient of variation less than 6%) as was the precision and accuracy (coefficient of variation less than 2.5%). No interference from endogenous substances or any of the common drugs tested was found.
DOI: 10.1016/0378-4347(91)80550-v PMID: 1797861 [Indexed for MEDLINE]
. Am J Roentgenol Radium Ther Nucl Med. 1966 Jul;97(3):755-61. doi: 10.2214/ajr.97.3.755.
Experimental evaluation of concentrated solutions of iothalamic acid derivatives as angiographic contrast media.
Hayes CW, Foster JH, Sewell R, Killen DA.
DOI: 10.2214/ajr.97.3.755 PMID: 5927620 [Indexed for MEDLINE]
. Boll Soc Ital Biol Sper. 1978 Dec 30;54(24):2583-9.
[Quantiative determination of radiopaque contrast media by means of HPLC. I. Determination of diatrizoic acid, iothalamic acid and iodamide].
[Article in Italian]
La Rotonda MI, Schettino O.
A rapid method for the quantitative analysis of radiopaque contrast media HPLC is described. Method can greatly help in solving problems of clinical and forensic interest.
PMID: 756280 [Indexed for MEDLINE]