Iotalamic acid

• CAT Number: I002737
• CAS Number: 2276-90-6
• Molecular Formula: C11H9I3N2O4
• Molecular Weight: 613.91
• Purity: ≥95%
• Solubility: 10 mM in DMSO
• Storage: -20°C
• IUPAC Name: 3-acetamido-2,4,6-triiodo-5-(methylcarbamoyl)benzoic acid
• InChI: InChI=1S/C11H9I3N2O4/c1-3(17)16-9-7(13)4(10(18)15-2)6(12)5(8(9)14)11(19)20/h1-2H3,(H,15,18)(H,16,17)(H,19,20)
• InChIKey: UXIGWFXRQKWHHA-UHFFFAOYSA-N
• SMILES: CC(=O)NC1=C(C(=C(C(=C1I)C(=O)O)I)C(=O)NC)I

Iothalamic Acid (CAT: I002737) is an ionic tri-iodinated benzoate compound that is commonly used as a contrast agent in diagnostic imaging procedures. It is primarily employed in radiographic examinations such as X-rays, computed tomography (CT), and angiography to enhance the visibility of certain tissues and organs. Iothalamic Acid, when administered intravenously or orally, selectively accumulates in specific areas of the body, allowing for improved visualization and delineation of anatomical structures during medical imaging. Its use helps healthcare professionals obtain clearer and more accurate diagnostic information. As a contrast agent, Iothalamic Acid undergoes rapid elimination from the body after imaging procedures.

Reference

[1]. Ann Pharm Fr. 1972 Jun;30(6):473-6.
[Iothalamic acid].
[Article in French]
[No authors listed]
PMID: 4638742 [Indexed for MEDLINE]

[2]. J Pharm Sci. 1963 Dec;52:1180-2.
QUALITATIVE AND QUANTITATIVE TESTS FOR IOTHALAMIC ACID.
CADWALLADER DE.
PMID: 14088971 [Indexed for MEDLINE]

[3]. J Chromatogr. 1991 Oct 4;570(2):435-40. doi: 10.1016/0378-4347(91)80550-v.
High-performance liquid chromatographic determination of iothalamic acid in human plasma and urine.
Gaspari F(1), Mainardi L, Ruggenenti P, Remuzzi G.
Author information: (1)Mario Negri Institute for Pharmacological Research, Laboratory of Clinical Pharmacokinetics, Bergamo, Italy.
A simple, rapid and sensitive method for the determination of iothalamic acid (IA) in both plasma and urine is reported. After extraction with ethyl acetate, IA was determined by strong anion-exchange high-performance liquid chromatography with ultraviolet detection at 254 nm. The lower limit of detection was 0.5 micrograms/ml. The average recovery was 73 and 57% from plasma and urine, respectively. Linearity was found over the investigated concentration range (up to 500 micrograms/ml for plasma and up to 10.0 mg/ml for urine). The reproducibility of the technique was good (coefficient of variation less than 6%) as was the precision and accuracy (coefficient of variation less than 2.5%). No interference from endogenous substances or any of the common drugs tested was found.
DOI: 10.1016/0378-4347(91)80550-v PMID: 1797861 [Indexed for MEDLINE]

[4]. Am J Roentgenol Radium Ther Nucl Med. 1966 Jul;97(3):755-61. doi: 10.2214/ajr.97.3.755.
Experimental evaluation of concentrated solutions of iothalamic acid derivatives as angiographic contrast media.
Hayes CW, Foster JH, Sewell R, Killen DA.
DOI: 10.2214/ajr.97.3.755 PMID: 5927620 [Indexed for MEDLINE]

[5]. Boll Soc Ital Biol Sper. 1978 Dec 30;54(24):2583-9.
[Quantiative determination of radiopaque contrast media by means of HPLC. I. Determination of diatrizoic acid, iothalamic acid and iodamide].
[Article in Italian]
La Rotonda MI, Schettino O.
A rapid method for the quantitative analysis of radiopaque contrast media HPLC is described. Method can greatly help in solving problems of clinical and forensic interest.
PMID: 756280 [Indexed for MEDLINE]