CAS No. : 124083-20-1

Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000961
Synonyms:ethyl (2R)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate
Molecular Formula:C₁₇H₂₃ClO₄
Molecular Weight:326.81
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Cat No:I000961
Cas No:124083-20-1
MDL No:MFCD11227266

Etomoxir is a cell-permeable, irreversible, and stereospecific inhibitor of carnitine palmitoyltransferase (CPT)-1 and DGAT activity in the mitochondria of rat heart H9c2 myoblastic cells at a concentration of 1-80 μM and 40 μM, respectively.
IC50 value:
Target: CPT1/DGAT

[1]. Abbas HG, Yunus M, Feinendegen LE.Radiochemical synthesis of etomoxir.Appl Radiat Isot. 2011 Feb;69(2):415-7. Epub 2010 Oct 19.
[2]. Schwarzer M, Faerber G, Rueckauer T, Blum D, Pytel G, Mohr FW, Doenst T.The metabolic modulators, Etomoxir and NVP-LAB121, fail to reverse pressure overload induced heart failure in vivo.Basic Res Cardiol. 2009 Sep;104(5):547-57. Epub 2009 Mar 14.
[3]. Luiken JJ, Niessen HE, Coort SL, Hoebers N, Coumans WA, Schwenk RW, Bonen A, Glatz JF.Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates.Biochem J. 2009 Apr 15;419(2):447-55.

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