(R)-(+)-Etomoxir

• CAT Number: I000961
• CAS Number: 124083-20-1
• Molecular Formula: C₁₇H₂₃ClO₄
• Molecular Weight: 326.81
• Purity: ≥95%
• Target: CPT1
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• InChI: InChI=1S/C17H23ClO4/c1-2-20-16(19)17(13-22-17)11-5-3-4-6-12-21-15-9-7-14(18)8-10-15/h7-10H,2-6,11-13H2,1H3/t17-/m0/s1
• InChIKey: DZLOHEOHWICNIL-KRWDZBQOSA-N
• SMILES: CCOC(=O)C1(CO1)CCCCCCOC2=CC=C(C=C2)Cl

Etomoxir(CAT: I000961) is a cell-permeable and irreversible inhibitor of carnitine palmitoyltransferase (CPT)-1 and diacylglycerol O-acyltransferase (DGAT) activity, operating within the mitochondria of rat heart H9c2 myoblastic cells. It achieves this inhibition with a stereospecific effect at concentrations ranging from 1 to 80 μM for CPT-1 and at 40 μM for DGAT. Through its action, Etomoxir disrupts fatty acid oxidation and triglyceride synthesis, exerting a regulatory influence on cellular energy metabolism.

Reference

[1]. Abbas HG, Yunus M, Feinendegen LE.Radiochemical synthesis of etomoxir.Appl Radiat Isot. 2011 Feb;69(2):415-7. Epub 2010 Oct 19.
[2]. Schwarzer M, Faerber G, Rueckauer T, Blum D, Pytel G, Mohr FW, Doenst T.The metabolic modulators, Etomoxir and NVP-LAB121, fail to reverse pressure overload induced heart failure in vivo.Basic Res Cardiol. 2009 Sep;104(5):547-57. Epub 2009 Mar 14.
[3]. Luiken JJ, Niessen HE, Coort SL, Hoebers N, Coumans WA, Schwenk RW, Bonen A, Glatz JF.Etomoxir-induced partial carnitine palmitoyltransferase-I (CPT-I) inhibition in vivo does not alter cardiac long-chain fatty acid uptake and oxidation rates.Biochem J. 2009 Apr 15;419(2):447-55.