MX69


CAS No. : 1005264-47-0

MX69,1005264-47-0
Product Details
For research use only. Not Intended for Therapeutic Use!
Cat No:I000088
Molecular Formula:C₂₇H₂₆N₂O₄S
Molecular Weight:474.58
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Appearance:Solid powder
Purity: > 98%
Cat No:I000088
Cas No:1005264-47-0
Product-Name:MX69
InChI:InChI=1S/C27H26N2O4S/c1-16-6-11-20(14-17(16)2)29-34(32,33)21-12-13-25-24(15-21)22-4-3-5-23(22)26(28-25)18-7-9-19(10-8-18)27(30)31/h3-4,6-15,22-23,26,28-29H,5H2,1-2H3,(H,30,31)
InChIKey:XCBONKHCCRJMNW-UHFFFAOYSA-N
SMILES:CC1=C(C=C(C=C1)NS(=O)(=O)C2=CC3=C(C=C2)NC(C4C3C=CC4)C5=CC=C(C=C5)C(=O)O)C

MX69 is the MDM2/XIAP inhibitor, used for cancer treatment.
MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models. MX69-induced MDM2 downregulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro and inhibition of cancer cell proliferation in vivo.


[1]. Gu L, et al. Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. Cancer Cell. 2016 Oct 10;30(4):623-636.

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