CAS No. : 71963-77-4

Product Details
Cat No:A000567
Synonyms:Beta-Artemether; Dihydroartemisinin methyl ether; Artenam; 71963-77-4; Artemetherum
Molecular Formula:C16H26O5
Molecular Weight:298.4
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Appearance:Solid powder
Purity: > 98%
Cat No:A000567
Cas No:71963-77-4

It has highly effective action against the blood schizonts of both malarial parasites P. falciparum and P. Vivax. Artemether has been shown to have significant anticancer and antitumor activities. Artemether has analgesic and antipyretic effects on the body by relieving pain and reducing fever.

Sesquiterpenoidderivative of Artemisinin, originally isolated from Artemisia annua

The generally accepted mechanism of action of peroxide antimalarials involves interaction of the peroxide-containing drug with heme, a hemoglobin degradation byproduct, derived from proteolysis of hemoglobin. This interaction is believed to result in the formation of a range of potentially toxic oxygen and carbon-centered radicals.

1: Hasegawa C, Kudo M, Maruyama H, Kimura M. Severe delayed haemolytic anaemia associated with artemether-lumefantrine treatment of malaria in a Japanese traveller. J Infect Chemother. 2017 Nov 7. pii: S1341-321X(17)30241-6. doi: 10.1016/j.jiac.2017.10.008. [Epub ahead of print] PubMed PMID: 29127021.
2: Challenger JD, Bruxvoort K, Ghani AC, Okell LC. Assessing the impact of imperfect adherence to artemether-lumefantrine on malaria treatment outcomes using within-host modelling. Nat Commun. 2017 Nov 9;8(1):1373. doi: 10.1038/s41467-017-01352-3. PubMed PMID: 29123086.
3: Zhao X, Guo X, Yue W, Wang J, Yang J, Chen J. Artemether suppresses cell proliferation and induces apoptosis in diffuse large B cell lymphoma cells. Exp Ther Med. 2017 Nov;14(5):4083-4090. doi: 10.3892/etm.2017.5063. Epub 2017 Aug 29. PubMed PMID: 29104626; PubMed Central PMCID: PMC5658687.
4: van der Meulen T, Lee S, Noordeloos E, Donaldson CJ, Adams MW, Noguchi GM, Mawla AM, Huising MO. Artemether Does Not Turn α Cells into β Cells. Cell Metab. 2017 Nov 1. pii: S1550-4131(17)30614-9. doi: 10.1016/j.cmet.2017.10.002. [Epub ahead of print] PubMed PMID: 29103923.
5: Mangrio FA, Dwivedi P, Han S, Zhao G, Gao D, Si T, Xu RX. Characteristics of Artemether-Loaded Poly(lactic-co-glycolic) Acid Microparticles Fabricated by Coaxial Electrospray: Validation of Enhanced Encapsulation Efficiency and Bioavailability. Mol Pharm. 2017 Nov 14. doi: 10.1021/acs.molpharmaceut.7b00862. [Epub ahead of print] PubMed PMID: 29096443.
6: Moore BR, Davis WA, Clarke PM, Robinson LJ, Laman M, Davis TME. Cost-effectiveness of artemisinin-naphthoquine versus artemether-lumefantrine for the treatment of uncomplicated malaria in Papua New Guinean children. Malar J. 2017 Oct 30;16(1):438. doi: 10.1186/s12936-017-2081-8. PubMed PMID: 29084540; PubMed Central PMCID: PMC5663042.
7: Huang L, Carey V, Lindsey JC, Marzan F, Gingrich D, Graham B, Barlow-Mosha L, Ssemambo PK, Kamthunzi P, Nachman S, Parikh S, Aweeka FT; IMPAACT P1079 protocol team. Concomitant nevirapine impacts pharmacokinetic exposure to the antimalarial artemether-lumefantrine in African children. PLoS One. 2017 Oct 24;12(10):e0186589. doi: 10.1371/journal.pone.0186589. eCollection 2017. PubMed PMID: 29065172; PubMed Central PMCID: PMC5655345.
8: Ali S, Jafery N, Farhat K, Waheed A. Mini Review - Analysis of Artemether and Dihydroartemisinin by high performance high liquid chromatography in biological fluids-issues and solutions. Pak J Pharm Sci. 2017 Jul;30(4):1395-1401. PubMed PMID: 29039344.
9: Tian L, Liu J, Jia Q, Ying Y, Yang Z, Huang G. Preparation and Evaluation of Artemether Liposomes for Enhanced Anti-Tumor Therapy. AAPS PharmSciTech. 2017 Oct 16. doi: 10.1208/s12249-017-0896-9. [Epub ahead of print] PubMed PMID: 29038986.
10: Abd El-Aal NF, Hamza RS, Magdy M. Anti-angiogenic and anti-lymphangiogenic role of praziquantel and artemether in experimental mansoniasis. Acta Parasitol. 2017 Dec 20;62(4):708-716. doi: 10.1515/ap-2017-0085. PubMed PMID: 29035850.
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