9,21-Dehydroryanodine

• CAT Number: T000073
• CAS Number: 94513-55-0
• Molecular Formula: C25H33NO9
• Molecular Weight: 491.53
• Purity: ≥95%
• Synonyms: 9,21-Didehydroryanodol 3-(1H-pyrrole-2-carboxylate)
• Solubility: Well in water under heating, methanol and ethanol
• Storage: Store tightly sealed at +4°C, in dark place.
• IUPAC Name: (2,6,9,11,13,14-hexahydroxy-7,10-dimethyl-3-methylidene-11-propan-2-yl-15-oxapentacyclo[7.5.1.01,6.07,13.010,14]pentadecan-12-yl) 1H-pyrrole-2-carboxylate
• InChI: InChI=1S/C25H33NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12,15,17,26-27,29-33H,3,8-9,11H2,1-2,4-5H3
• InChIKey: BPFNBBLVUYSFRK-UHFFFAOYSA-N
• SMILES: CC(C)C1(C(C2(C3(CC4(C1(C2(C5(C3(CCC(=C)C5O)O)O4)O)C)O)C)O)OC(=O)C6=CC=CN6)O

9,21-Dehydroryanodine（Cat No.:T000073）is a naturally derived diterpenoid and structural analog of ryanodine, isolated primarily from the Ryania plant genus. It features a complex polycyclic framework with the absence of hydroxyl groups at positions 9 and 21 compared to ryanodine, which alters its biological activity. Like ryanodine, it interacts with ryanodine receptors (RyRs) on intracellular calcium channels, modulating calcium ion release in muscle and neuronal cells. Its activity is of interest in pharmacological and toxicological studies related to muscle contraction, neurophysiology, and potential therapeutic targeting of calcium signaling pathways.