4SC-202 free base

• CAT Number: I005425
• CAS Number: 910462-43-0
• Molecular Formula: C23H21N5O3S
• Molecular Weight: 447.51
• Purity: ≥95%
• Target: HDAC1/2/3
• Solubility: DMSO: ≥ 58 mg/mL
• Storage: Store at -20℃
• IUPAC Name: (E)-N-(2-aminophenyl)-3-[1-[4-(1-methylpyrazol-4-yl)phenyl]sulfonylpyrrol-3-yl]prop-2-enamide
• InChI: InChI=1S/C23H21N5O3S.C7H8O3S/c1-27-16-19(14-25-27)18-7-9-20(10-8-18)32(30,31)28-13-12-17(15-28)6-11-23(29)26-22-5-3-2-4-21(22)24;1-6-2-4-7(5-3-6)11(8,9)10/h2-16H,24H2,1H3,(H,26,29);2-5H,1H3,(H,8,9,10)/b11-6+
• InChIKey: IAVXAZDVNICKFJ-ICSBZGNSSA-N
• SMILES: O=C(NC1=CC=CC=C1N)/C=C/C2=CN(S(=O)(C3=CC=C(C4=CN(C)N=C4)C=C3)=O)C=C2.O=S(C5=CC=C(C)C=C5)(O)=O

4SC-202 (Cat.No:I005425) is a small molecule inhibitor of the histone deacetylase (HDAC) and lysine-specific demethylase 1 (LSD1) enzymes. It has been investigated for its anti-tumor activity in various cancer types, including leukemia, lymphoma, and solid tumors. 4SC-202 has also shown potential as an immunomodulatory agent. The compound is available in its free base form and has been used in preclinical studies for its potential therapeutic applications.

Reference

[1]. S.W.Henning, et al. Preclinical characterization of 4SC-202, a noval isotype specific HDAC inhibitor