10074-G5

  • CAT Number: I000047
  • CAS Number: 413611-93-5
  • Molecular Formula: C18H12N4O3
  • Molecular Weight: 332.3
  • Purity: ≥95%
Inquiry Now

10074-G5 (CAT: I000047) is a small molecule inhibitor that specifically targets the interaction between the transcription factor c-Myc and its binding partner Max. By disrupting the c-Myc/Max complex, 10074-G5 inhibits the transcriptional activity of c-Myc, which is known to play a crucial role in cell proliferation and survival. This compound has demonstrated anti-tumor effects in various cancer cell lines and preclinical models. 10074-G5 has been studied for its potential therapeutic applications in cancer treatment, particularly in targeting c-Myc-driven malignancies. Its ability to inhibit c-Myc activity makes it a promising candidate for the development of novel anti-cancer therapies.

Catalog Number I000047
CAS Number 413611-93-5
Synonyms

10074-G5; 10074G5;;Biphenyl-2-yl-(7-nitrobenzo[1,2,5]oxadiazol-4-yl)amine

Molecular Formula

C18H12N4O3

Purity 95%
Target c-Myc
Solubility Soluble in DMSO
Storage 3 years -20C powder
InChI InChI=1S/C18H14N4O3/c23-22(24)18-11-10-16(17-12-19-25-21(17)18)20-15-9-5-4-8-14(15)13-6-2-1-3-7-13/h1-12,19-20H
InChIKey KMJPYSQOCBYMCF-UHFFFAOYSA-N
SMILES O=[N+](C(C1=NON=C12)=CC=C2NC3=CC=CC=C3C4=CC=CC=C4)[O-]
Reference

1: Yap JL, Wang H, Hu A, Chauhan J, Jung KY, Gharavi RB, Prochownik EV, Fletcher
S. Pharmacophore identification of c-Myc inhibitor 10074-G5. Bioorg Med Chem
Lett. 2013 Jan 1;23(1):370-4. doi: 10.1016/j.bmcl.2012.10.013. Epub 2012 Oct 17.
PubMed PMID: 23177256; PubMed Central PMCID: PMC3525812.</br>

2: Wang H, Chauhan J, Hu A, Pendleton K, Yap JL, Sabato PE, Jones JW, Perri M, Yu
J, Cione E, Kane MA, Fletcher S, Prochownik EV. Disruption of Myc-Max
heterodimerization with improved cell-penetrating analogs of the small molecule
10074-G5. Oncotarget. 2013 Jun;4(6):936-47. PubMed PMID: 23801058; PubMed Central
PMCID: PMC3757250.</br>
3: Clausen DM, Guo J, Parise RA, Beumer JH, Egorin MJ, Lazo JS, Prochownik EV,
Eiseman JL. In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and
metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max
dimerization. J Pharmacol Exp Ther. 2010 Dec;335(3):715-27. doi:
10.1124/jpet.110.170555. Epub 2010 Aug 26. PubMed PMID: 20801893; PubMed Central
PMCID: PMC2993546.

Request a Quote

Contact Us at MuseChem

We are committed to providing you with reliable, cost-effective solutions for your chemical needs, while ensuring your safety and comfort. Our team of experts is always available to answer your questions and help you navigate the complexities of the chemical industry.

Whether you're looking for a specific product or need help with a custom synthesis project, we're here to help you discover a new world of chemical possibilities. Contact us today to learn more about how we can assist you with all of your chemical needs.

Our goal is to make the process of ordering chemicals as seamless and hassle-free as possible. Let us know how we can assist you, and we'll get back to you as soon as possible. We look forward to hearing from you!