10074-G5

• CAT Number: I000047
• CAS Number: 413611-93-5
• Molecular Formula: C18H12N4O3
• Molecular Weight: 332.3
• Purity: ≥95%
• Target: c-Myc
• Solubility: Soluble in DMSO
• Storage: 3 years -20C powder
• InChI: InChI=1S/C18H14N4O3/c23-22(24)18-11-10-16(17-12-19-25-21(17)18)20-15-9-5-4-8-14(15)13-6-2-1-3-7-13/h1-12,19-20H
• InChIKey: KMJPYSQOCBYMCF-UHFFFAOYSA-N
• SMILES: O=[N+](C(C1=NON=C12)=CC=C2NC3=CC=CC=C3C4=CC=CC=C4)[O-]

10074-G5 (CAT: I000047) is a small molecule inhibitor that specifically targets the interaction between the transcription factor c-Myc and its binding partner Max. By disrupting the c-Myc/Max complex, 10074-G5 inhibits the transcriptional activity of c-Myc, which is known to play a crucial role in cell proliferation and survival. This compound has demonstrated anti-tumor effects in various cancer cell lines and preclinical models. 10074-G5 has been studied for its potential therapeutic applications in cancer treatment, particularly in targeting c-Myc-driven malignancies. Its ability to inhibit c-Myc activity makes it a promising candidate for the development of novel anti-cancer therapies.

Reference

1: Yap JL, Wang H, Hu A, Chauhan J, Jung KY, Gharavi RB, Prochownik EV, Fletcher
S. Pharmacophore identification of c-Myc inhibitor 10074-G5. Bioorg Med Chem
Lett. 2013 Jan 1;23(1):370-4. doi: 10.1016/j.bmcl.2012.10.013. Epub 2012 Oct 17.
PubMed PMID: 23177256; PubMed Central PMCID: PMC3525812.

2: Wang H, Chauhan J, Hu A, Pendleton K, Yap JL, Sabato PE, Jones JW, Perri M, Yu
J, Cione E, Kane MA, Fletcher S, Prochownik EV. Disruption of Myc-Max
heterodimerization with improved cell-penetrating analogs of the small molecule
10074-G5. Oncotarget. 2013 Jun;4(6):936-47. PubMed PMID: 23801058; PubMed Central
PMCID: PMC3757250.
3: Clausen DM, Guo J, Parise RA, Beumer JH, Egorin MJ, Lazo JS, Prochownik EV,
Eiseman JL. In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and
metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max
dimerization. J Pharmacol Exp Ther. 2010 Dec;335(3):715-27. doi:
10.1124/jpet.110.170555. Epub 2010 Aug 26. PubMed PMID: 20801893; PubMed Central
PMCID: PMC2993546.