AX-024

• CAT Number: I013060
• CAS Number: 1370544-73-2
• Molecular Formula: C₂₁H₂₂FNO₂
• Molecular Weight: 339.4
• Purity: ≥95%
• Target: IFNARInterleukin RelatedTNF-alpha
• Solubility: DMSO: 35 mg/mL
• Storage: Store at -20°C
• IUPAC Name: 1-[[4-(4-fluorophenyl)-6-methoxy-2H-chromen-3-yl]methyl]pyrrolidine
• InChI: InChI=1S/C21H22FNO2/c1-24-18-8-9-20-19(12-18)21(15-4-6-17(22)7-5-15)16(14-25-20)13-23-10-2-3-11-23/h4-9,12H,2-3,10-11,13-14H2,1H3
• InChIKey: VMMKGVRPILDZML-UHFFFAOYSA-N
• SMILES: COC1=CC2=C(C=C1)OCC(=C2C3=CC=C(C=C3)F)CN4CCCC4

AX-024（Cat No.:I013060） is a cytokine release inhibitor that demonstrates strong inhibition of several key cytokines. It effectively suppresses the production of interleukin-6 (IL-6), tumor necrosis factor-α (TNFα), interferon-γ (IFN-γ), IL-10, and IL-17A. By inhibiting the release of these cytokines, AX-024 may have potential applications in modulating immune responses and managing conditions associated with excessive cytokine production.

Reference

[1]. Borroto A, et al. First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases. Sci Transl Med. 2016 Dec 21;8(370):370ra184.