ZYZ-488

• CAT Number: I019134
• CAS Number: 1470302-79-4
• Molecular Formula: C₂₀H₂₉N₃O₁₁
• Molecular Weight: 487.46
• Purity: ≥95%

ZYZ-488 (CAT: I019134) pertains to its potential as an apoptotic protease activating factor-1 (Apaf-1) inhibitor. ZYZ-488 has been shown to inhibit the activation of procaspase-9 and procaspase-3, which are binding proteins involved in the apoptotic pathway. In hypoxic H9c2 cells, ZYZ-488 has demonstrated a decrease in apoptosis by inhibiting the Apaf-1-mediated activation of procaspase-9 and procaspase-3. Additionally, ZYZ-488 has shown a protective effect against myocardial apoptosis, reducing myocardial enzyme release, inhibiting cardiomyocyte apoptosis, and suppressing the activation of caspases. This suggests that ZYZ-488 may have potential therapeutic implications for conditions involving apoptotic pathways and myocardial health.

Reference

[1]. Wang Y, et al. The discovery of a novel inhibitor of apoptotic protease activating factor-1 (Apaf-1) for ischemic heart: synthesis, activity and target identification. Sci Rep. 2016 Jul 22;6:29820.