Zuvotolimod

• CAT Number: I045082
• CAS Number: 2355262-97-2
• Molecular Formula: C55H70N12O10
• Molecular Weight: 1059.22
• Purity: ≥95%
• Synonyms: [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl 3-[[2-amino-4-(dipropylcarbamoyl)-3H-1-benzazepine-8-carbonyl]amino]-7,8-dihydro-5H-1,6-naphthyridine-6-carboxylate
• InChI: InChI=1S/C55H70N12O10/c1-5-23-65(24-6-2)53(74)38-27-36-15-16-37(29-44(36)62-45(56)30-38)50(71)61-41-28-39-32-66(26-21-42(39)59-31-41)55(76)77-33-35-13-17-40(18-14-35)60-51(72)43(11-10-22-58-54(57)75)63-52(73)49(34(3)4)64-46(68)12-8-7-9-25-67-47(69)19-20-48(67)70/h13-20,27-29,31,34,43,49H,5-12,21-26,30,32-33H2,1-4H3,(H2,56,62)(H,60,72)(H,61,71)(H,63,73)(H,64,68)(H3,57,58,75)/t43-,49-/m0/s1
• InChIKey: JMDJMYUCIGMITJ-UCNLINEOSA-N
• SMILES: CCCN(CCC)C(=O)C1=CC2=C(C=C(C=C2)C(=O)NC3=CC4=C(CCN(C4)C(=O)OCC5=CC=C(C=C5)NC(=O)[C@H](CCCNC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)CCCCCN6C(=O)C=CC6=O)N=C3)N=C(C1)N

Zuvotolimod (Cat No.:I045082) is a Toll-like receptor 9 (TLR9) agonist designed to stimulate innate and adaptive immune responses, primarily in cancer and infectious diseases. It activates plasmacytoid dendritic cells and induces type I interferons and other cytokines, promoting T cell- and NK cell-mediated antitumor activity. Administered subcutaneously, zuvotolimod has shown clinical promise in metastatic colorectal cancer, non-small cell lung cancer, and as a potential immunotherapy enhancer. Its well-tolerated safety profile and ability to synergize with checkpoint inhibitors make it a compelling candidate in immuno-oncology strategies.