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Zonisamide

Zonisamide

  • CAT Number: A000801
  • CAS Number: 68291-97-4
  • Molecular Formula: C8H8N2O3S
  • Molecular Weight: 212.23
  • Purity: ≥95%
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Zonisamide( CAS 68291-97-4)&nbsp;is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures; infantile spasm, mixed seizure types of Lennox&ndash;Gastaut syndrome, myoclonic, and generalized tonic clonic seizure.&nbsp;<span style="font-size:12px;"><span style="font-family: -apple-system, system-ui, &quot;Segoe UI&quot;, Roboto, Oxygen, Oxygen-Sans, Ubuntu, Cantarell, &quot;Fira Sans&quot;, &quot;Droid Sans&quot;, &quot;Helvetica Neue&quot;, &quot;Source Sans Pro&quot;, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;">Zonisamide appears to block sodium&nbsp;</span><span style="font-family: -apple-system, system-ui, &quot;Segoe UI&quot;, Roboto, Oxygen, Oxygen-Sans, Ubuntu, Cantarell, &quot;Fira Sans&quot;, &quot;Droid Sans&quot;, &quot;Helvetica Neue&quot;, &quot;Source Sans Pro&quot;, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;">and&nbsp;</span><span style="font-family: -apple-system, system-ui, &quot;Segoe UI&quot;, Roboto, Oxygen, Oxygen-Sans, Ubuntu, Cantarell, &quot;Fira Sans&quot;, &quot;Droid Sans&quot;, &quot;Helvetica Neue&quot;, &quot;Source Sans Pro&quot;, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;">calcium channels, thereby stabilizing neuronal membranes and suppressing neuronal hyper-synchronization. Although zonisamide shows affinity for the gamma-aminobutyric acid (GABA)/benzodiazepine&nbsp;</span><span style="font-family: -apple-system, system-ui, &quot;Segoe UI&quot;, Roboto, Oxygen, Oxygen-Sans, Ubuntu, Cantarell, &quot;Fira Sans&quot;, &quot;Droid Sans&quot;, &quot;Helvetica Neue&quot;, &quot;Source Sans Pro&quot;, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;">receptor ionophore complex, it does not potentiate the synaptic activity of GABA.</span><span style="font-family: -apple-system, system-ui, &quot;Segoe UI&quot;, Roboto, Oxygen, Oxygen-Sans, Ubuntu, Cantarell, &quot;Fira Sans&quot;, &quot;Droid Sans&quot;, &quot;Helvetica Neue&quot;, &quot;Source Sans Pro&quot;, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;">&nbsp;In addition, this agent also facilitates both dopaminergic and serotonergic neurotransmission.</span></span>

Catalog Number A000801
CAS Number 68291-97-4
Molecular Formula

C8H8N2O3S

Purity 95%
Target Calcium Channel
Solubility >8.4mg/mL in DMSO
Storage -20°C
Overview of Clinical Research

<span style="font-size:12px;">The phase IV study of&nbsp;Zonisamide on&nbsp;<span style="caret-color: rgb(51, 51, 51); font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, sans-serif;">&nbsp;Parkinson&#39;s disease is completed. The phase I study of&nbsp;</span>Zonisamide on n<span style="caret-color: rgb(51, 51, 51); font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, sans-serif;">eurological disorders and &nbsp;partial epilepsies is active.&nbsp;</span></span>

IUPAC Name 1,2-benzoxazol-3-ylmethanesulfonamide
InChI InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12)
InChIKey UBQNRHZMVUUOMG-UHFFFAOYSA-N
SMILES C1=CC=C2C(=C1)C(=NO2)CS(=O)(=O)N
Reference

1: Zareba G. Zonisamide: review of its use in epilepsy therapy. Drugs Today (Barc). 2005 Sep;41(9):589-97. Review. PubMed PMID: 16341290.<br />
2: Leppik IE. Zonisamide: chemistry, mechanism of action, and pharmacokinetics. Seizure. 2004 Dec;13 Suppl 1:S5-9; discussion S10. Review. PubMed PMID: 15511691.<br />
3: Peters DH, Sorkin EM. Zonisamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in epilepsy. Drugs. 1993 May;45(5):760-87. Review. PubMed PMID: 7686468.<br />
4: Hammond EJ, Perchalski RJ, Wilder BJ, McLean JR. Neuropharmacology of zonisamide, a new antiepileptic drug. Gen Pharmacol. 1987;18(3):303-7. Review. PubMed PMID: 3552863.

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