For research use only. Not for therapeutic Use.
ZM223 hydrochloride（Cat No.:I046132）is a selective and potent antagonist of the serotonin 5-HT₁B receptor, a G protein–coupled receptor involved in mood regulation, vasoconstriction, and neurotransmission. By blocking 5-HT₁B signaling, ZM223 hydrochloride has been used to study mechanisms underlying depression, migraine, and other neuropsychiatric or vascular disorders. Its receptor selectivity makes it a valuable pharmacological tool for dissecting serotonergic pathways and their role in brain function and cardiovascular physiology. Researchers employ ZM223 hydrochloride to explore therapeutic strategies targeting serotonergic dysregulation in disease models.
| CAS Number | 2438679-27-5 |
| Synonyms | N-[6-[[2-(4-aminophenyl)sulfanylacetyl]amino]-1,3-benzothiazol-2-yl]-4-(trifluoromethyl)benzamide;hydrochloride |
| Molecular Formula | C23H18ClF3N4O2S2 |
| Purity | ≥95% |
| IUPAC Name | N-[6-[[2-(4-aminophenyl)sulfanylacetyl]amino]-1,3-benzothiazol-2-yl]-4-(trifluoromethyl)benzamide;hydrochloride |
| InChI | InChI=1S/C23H17F3N4O2S2.ClH/c24-23(25,26)14-3-1-13(2-4-14)21(32)30-22-29-18-10-7-16(11-19(18)34-22)28-20(31)12-33-17-8-5-15(27)6-9-17;/h1-11H,12,27H2,(H,28,31)(H,29,30,32);1H |
| InChIKey | DXCZCDSLNIYJQF-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1C(=O)NC2=NC3=C(S2)C=C(C=C3)NC(=O)CSC4=CC=C(C=C4)N)C(F)(F)F.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
