ZL0590

• CAT Number: I044145
• CAS Number: 2230496-99-6
• Molecular Formula: C23H27F3N4O4S
• Molecular Weight: 512.55
• Purity: ≥95%
• Synonyms: 1-[4-[(2S)-2-(morpholin-4-ylmethyl)pyrrolidin-1-yl]sulfonylphenyl]-3-[4-(trifluoromethyl)phenyl]urea
• InChI: InChI=1S/C23H27F3N4O4S/c24-23(25,26)17-3-5-18(6-4-17)27-22(31)28-19-7-9-21(10-8-19)35(32,33)30-11-1-2-20(30)16-29-12-14-34-15-13-29/h3-10,20H,1-2,11-16H2,(H2,27,28,31)/t20-/m0/s1
• InChIKey: ZPMULUKHFNMJPF-FQEVSTJZSA-N
• SMILES: C1C[C@H](N(C1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)NC3=CC=C(C=C3)C(F)(F)F)CN4CCOCC4

ZL0590（Cat No.:I044145）is a selective inhibitor of estrogen-related receptor alpha (ERRα), a nuclear receptor involved in energy metabolism, mitochondrial biogenesis, and cancer progression. By targeting ERRα, ZL0590 suppresses its transcriptional activity, thereby modulating metabolic gene expression and inhibiting tumor cell proliferation in ERRα-driven cancers. It is commonly used in metabolic and oncology research to explore the role of ERRα in diseases such as breast cancer, prostate cancer, and metabolic syndromes. ZL0590 serves as a valuable chemical probe for investigating ERRα’s regulatory mechanisms and its potential as a therapeutic target.