Dorsmorphin dihydrochloride

• CAT Number: I000838
• CAS Number: 1219168-18-9
• Molecular Formula: C₂₄H₂₅N₅O.2HCl
• Molecular Weight: 472.41
• Purity: ≥95%
• Target: AMPK
• Solubility: DMSO: ≤ 5.2 mg/mL (Need ultrasonic)
• Storage: Store at -20 C
• IC50: 109 nM (Ki for AMPK)
• InChI: InChI=1S/C24H25N5O.2ClH/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20;;/h4-11,16-18H,1-3,12-15H2;2*1H
• InChIKey: RJDVIJJQKMGPMV-UHFFFAOYSA-N
• SMILES: C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl

Dorsomorphin 2HCl (Cat No.:I000838) is a potent, reversible, and selective AMPK inhibitor with Ki of 109 nM in a cell-free assay against several structurally related kinases, including ZAPK, SYK, PKCθ, PKA and There was no significant inhibitory effect of JAK3. Also inhibits type I BMP receptors. Dorsomorphin also induces autophagy in cancer cell lines.

Reference

[1]. Jin J, et al. AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells. J Lipid Res. 2009 Dec;50(12):2389-97.
[2]. Saito S, et al. Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling. PLoS One. 2012;7(9):e45845.
[3]. Vucicevic L, et al. Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway. Autophagy. 2011 Jan;7(1):40-50.