ZL006

• CAT Number: I000643
• CAS Number: 1181226-02-7
• Molecular Formula: C14H11Cl2NO4
• Molecular Weight: 328.15
• Purity: ≥95%
• Target: PSD95-nNOS inhibitor
• Solubility: DMSO: ≥ 29 mg/mL
• Storage: 2-8°C
• IUPAC Name: 4-[(3,5-dichloro-2-hydroxyphenyl)methylamino]-2-hydroxybenzoic acid
• InChI: InChI=1S/C14H11Cl2NO4/c15-8-3-7(13(19)11(16)4-8)6-17-9-1-2-10(14(20)21)12(18)5-9/h1-5,17-19H,6H2,(H,20,21)
• InChIKey: RTEYSQSXRFVKTJ-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C=C1NCC2=C(C(=CC(=C2)Cl)Cl)O)O)C(=O)O

ZL006（Cat No.:I000643）, is a chemical compound with significance in pharmacology and neuroscience research. It acts as a selective inhibitor, primarily targeting the enzyme nNOS (neuronal nitric oxide synthase). This inhibition can potentially modulate nitric oxide (NO) production in the nervous system. Researchers use ZL006 to investigate the role of nNOS and NO signaling in various neurological processes and conditions, including neurodegenerative diseases and neuroinflammation. By providing insights into these mechanisms, ZL006 contributes to our understanding of brain function and may have implications for the development of therapies targeting NO-related pathways in neurological disorders.

Reference

1:ZL006 promotes migration and differentiation of transplanted neural stem cells in male rats after stroke. Wang DL, Qian XD, Lin YH, Tian BB, Liang HY, Chang L, Wu HY, Zhu DY, Luo CX.J Neurosci Res. 2017 May 17. doi: 10.1002/jnr.24068. [Epub ahead of print] PMID: 28512996 2:ZL006 protects spinal cord neurons against ischemia-induced oxidative stress through AMPK-PGC-1α-Sirt3 pathway. Liu SG, Wang YM, Zhang YJ, He XJ, Ma T, Song W, Zhang YM.Neurochem Int. 2017 Apr 12. pii: S0197-0186(17)30092-X. doi: 10.1016/j.neuint.2017.04.005. [Epub ahead of print] PMID: 28411102 3:Metabolic investigation on ZL006 for the discovery of a potent prodrug for the treatment of cerebral ischemia. Chen D, Zhao T, Ni K, Dai P, Yang L, Xu Y, Li F.Bioorg Med Chem Lett. 2016 May 1;26(9):2152-5. doi: 10.1016/j.bmcl.2016.03.074. Epub 2016 Mar 19. PMID: 27025341 4:Enhanced anti-ischemic stroke of ZL006 by T7-conjugated PEGylated liposomes drug delivery system. Wang Z, Zhao Y, Jiang Y, Lv W, Wu L, Wang B, Lv L, Xu Q, Xin H.Sci Rep. 2015 Jul 29;5:12651. doi: 10.1038/srep12651. PMID: 26219474 Free PMC Article5:Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions. Bach A, Pedersen SW, Dorr LA, Vallon G, Ripoche I, Ducki S, Lian LY.Sci Rep. 2015 Jul 16;5:12157. doi: 10.1038/srep12157. PMID: 26177569 Free PMC Article