Zileuton

• CAT Number: A000793
• CAS Number: 111406-87-2
• Molecular Formula: C11H12N2O2S
• Molecular Weight: 236.3
• Purity: ≥95%
• Target: 5-Lipoxygenase
• Solubility: >13.3mg/mL in DMSO
• Storage: -20°C
• InChI: 1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14)
• InChIKey: MWLSOWXNZPKENC-UHFFFAOYSA-N
• SMILES: CC(C1=CC2=CC=CC=C2S1)N(C(=O)N)O

Zileuton is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation. Zileuton is used for the maintenance treatment of asthma. Zileuton was introduced in 1996.

Reference

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Antidepressant-like effect of zileuton is accompanied by hippocampal
neuroinflammation reduction and CREB/BDNF upregulation in
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2: Saul D, Ninkovic M, Komrakova M, Wolff L, Gasimov T, Menger B, Hoffmann DB,
Rohde V, Sehmisch S. Effect of zileuton on osteoporotic bone and its healing,
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4: Saul D, Gleitz S, Nguyen HH, Kosinsky RL, Sehmisch S, Hoffmann DB, Wassmann M,
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5: Sarret C, Pichard S, Afenjar A, Boespflug-Tanguy O. Lack of Long-Term
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7: Krutetskaya ZI, Milenina LS, Naumova AA, Antonov VG, Nozdrachev AD.
5-Lipoxygenase inhibitor zileuton inhibits Ca(2+)-responses induced by glutoxim
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8: Tu XK, Zhang HB, Shi SS, Liang RS, Wang CH, Chen CM, Yang WZ. 5-LOX Inhibitor
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Activation of PI3K/Akt Signaling Pathway. Neurochem Res. 2016
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9: Magazine R, Shahul HA, Chogtu B, Kamath A. Comparison of oral montelukast with
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10: Morina N, Boçari G, Iljazi A, Hyseini K, Halac G. Maximum Time of the Effect
of Antileukotriene – Zileuton in Treatment of Patients with Bronchial Asthma.
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