Zebularine

• CAT Number: I000041
• CAS Number: 3690-10-6
• Molecular Formula: C₉H₁₂N₂O₅
• Molecular Weight: 228.2
• Purity: ≥95%
• Target: DNA Methyltransferase
• Solubility: DMSO: ≥ 45 mg/mL
• Storage: 2-8°C
• IUPAC Name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
• InChI: InChI=1S/C9H12N2O5/c12-4-5-6(13)7(14)8(16-5)11-3-1-2-10-9(11)15/h1-3,5-8,12-14H,4H2/t5-,6-,7-,8-/m1/s1
• InChIKey: RPQZTTQVRYEKCR-WCTZXXKLSA-N
• SMILES: C1=CN(C(=O)N=C1)C2C(C(C(O2)CO)O)O

Zebularine (Cat No.:I000041), also known as NSC 309132, 4-Deoxyuridine, is a DNA methylation inhibitor, forms a covalent complex with DNA methyltransferases, and also inhibits cytidine deaminase, with a Ki of 2 μM in a cell-free assay. If you need, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

[1]. Zhou L, et al. Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases. J Mol Biol, 2002, 321(4), 591-599.
[2]. Lemaire M, et al. Inhibition of cytidine deaminase by zebularine enhances the antineoplastic action of 5-aza-2/’-deoxycytidine. Cancer Chemother Pharmacol, 2009, 63(3), 411-416.
[3]. Cheng JC, et al. Inhibition of DNA methylation and reactivation of silenced genes by zebularine. J Natl Cancer Inst, 2003, 95(5), 399-409.
[4]. Cheng JC, et al. Preferential response of cancer cells to zebularine. Cancer Cell, 2004, 6(2), 151-158.