Z-WEHD-FMK

• CAT Number: I011541
• CAS Number: 210345-00-9
• Molecular Formula: C37H42FN7O10
• Molecular Weight: 763.78
• Purity: ≥95%
• Synonyms: methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-4-[[(2S)-3-(1H-indol-3-yl)-2-(phenylmethoxycarbonylamino)propanoyl]amino]-5-oxopentanoate
• Target: Caspase
• Storage: Store at -20°C
• InChI: InChI=1S/C37H42FN7O10/c1-53-32(47)13-12-27(34(49)44-30(15-24-19-39-21-41-24)36(51)43-28(31(46)17-38)16-33(48)54-2)42-35(50)29(14-23-18-40-26-11-7-6-10-25(23)26)45-37(52)55-20-22-8-4-3-5-9-22/h3-11,18-19,21,27-30,40H,12-17,20H2,1-2H3,(H,39,41)(H,42,50)(H,43,51)(H,44,49)(H,45,52)/t27-,28-,29-,30-/m0/s1
• InChIKey: NLZNSSWGRVBWIX-KRCBVYEFSA-N
• SMILES: COC(=O)CCC(C(=O)NC(CC1=CN=CN1)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)OCC4=CC=CC=C4

Z-WEHD-FMK (CAT: I011541) is a cell-permeable and irreversible inhibitor of caspase-1 and caspase-4, which are enzymes involved in programmed cell death or apoptosis. Z-WEHD-FMK works by irreversibly binding to the active site of the caspases, preventing them from carrying out their normal cellular functions. The inhibition of caspase-1 and caspase-4 activity by Z-WEHD-FMK has been shown to reduce the production of proinflammatory cytokines, such as interleukin-1 beta (IL-1β) and interleukin-18 (IL-18), and to prevent cell death in various experimental models of inflammation and apoptosis. Z-WEHD-FMK has been used as a tool compound to study the role of caspases in various cellular processes and as a potential therapeutic agent for the treatment of inflammatory and autoimmune diseases.