Z-DEVD-FMK

• CAT Number: I002617
• CAS Number: 210344-95-9
• Molecular Formula: C30H41FN4O12
• Molecular Weight: 668.7
• Purity: ≥95%
• Target: Caspase
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• InChIKey: GBJVAVGBSGRRKN-JYEBCORGSA-N

Z-DEVD-FMK (CAT: I002617) is a synthetic peptide-based compound that acts as an inhibitor of caspase-3, a key enzyme involved in the process of apoptosis (programmed cell death). It belongs to the class of peptide-based caspase inhibitors known as FMKs (fluoromethylketones). Z-DEVD-FMK specifically targets the active site of caspase-3, irreversibly inhibiting its activity and preventing the activation of downstream apoptotic pathways. This compound is commonly used in laboratory research to study the role of caspase-3 in cellular processes, apoptosis-related diseases, and to explore potential therapeutic interventions targeting apoptosis.

Reference

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[2]. Yakovlev AG, et al. Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J Neurosci. 1997, 17(19), 7415-7424.
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[4]. Kanthasamy AG, et al. A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson/’s disease models. Free Radic Biol Med. 2006, 41(10), 1578-1589.