Yohimbine

• CAT Number: I001776
• CAS Number: 146-48-5
• Molecular Formula: C21H26N2O3
• Molecular Weight: 354.44
• Purity: ≥95%
• Target: alpha 2-adrenergic receptor
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 0.6 uM [1]
• IUPAC Name: methyl (1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
• InChI: InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1
• InChIKey: BLGXFZZNTVWLAY-SCYLSFHTSA-N
• SMILES: COC(=O)[C@H]1[C@H](CC[C@@H]2[C@@H]1C[C@H]3C4=C(CCN3C2)C5=CC=CC=C5N4)O

Yohimbine (Cat.No:I001776) is a naturally occurring alkaloid found in the bark of the yohimbe tree. It is known for its use as a traditional aphrodisiac and has been investigated for its potential in treating erectile dysfunction and anxiety-related disorders. However, caution is advised due to potential side effects and interactions with certain medications.

Reference

[1]. Saeed SA, et al. Signaling mechanisms mediated by G-protein coupled receptors in human platelets. Acta Pharmacol Sin. 2004 Jul;25(7):887-892.

[2]. Blanchard RJ, et al. Yohimbine potentiates active defensive responses to threatening stimuli in Swiss-Webster mice. Pharmacol Biochem Behav. 1993 Mar;44(3):673-681.

[3]. Fuller BB, et al. Downregulation of tyrosinase activity in human melanocyte cell cultures by yohimbine. J Invest Dermatol. 2000 Feb;114(2):268-276.