YM-90709

• CAT Number: I002129
• CAS Number: 163769-88-8
• Molecular Formula: C₂₂H₂₁N₃O₂
• Molecular Weight: 359.43
• Purity: ≥95%
• Target: Cytokine
• Solubility: 10 mM in DMSO
• Storage: Store at RT
• InChI: InChI=1S/C22H21N3O2/c1-22(2)12-13-9-19(26-3)20(27-4)10-14(13)18-11-17-21(25(18)22)24-16-8-6-5-7-15(16)23-17/h5-11H,12H2,1-4H3
• InChIKey: HIXSPVQXXDULHS-UHFFFAOYSA-N
• SMILES: CC1(CC2=CC(=C(C=C2C3=CC4=NC5=CC=CC=C5N=C4N31)OC)OC)C

YM-90709(CAT: I002129) is a novel antagonist that effectively inhibits the binding of interleukin-5 (IL-5) to its receptor, interleukin-5 receptor (IL-5R). By disrupting the interaction between IL-5 and IL-5R, YM-90709 holds the potential for regulating immune responses and inflammatory processes involving IL-5 signaling. This inhibition could contribute to the development of therapeutic strategies targeting IL-5-mediated conditions, such as allergic diseases and eosinophilic disorders, providing opportunities for improved treatment approaches in these areas of medical concern.

Reference

1:Effect of a novel interleukin-5 receptor antagonist, YM-90709, on antigen-induced eosinophil infiltration into the airway of BDF1 mice. Morokata T, Suzuki K, Ida K, Yamada T.Immunol Lett. 2005 Apr 15;98(1):161-5. Epub 2004 Nov 28. PMID: 15790522 2:Effect of a novel interleukin-5 receptor antagonist, YM-90709 (2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo[7,8]indolizino[2,3-b]quinoxaline), on antigen-induced airway inflammation in BN rats. Morokata T, Suzuki K, Ida K, Tsuchiyama H, Ishikawa J, Yamada T.Int Immunopharmacol. 2004 Jul;4(7):873-83. PMID: 15182727 3:Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor. Morokata T, Ida K, Yamada T.Int Immunopharmacol. 2002 Nov;2(12):1693-702. PMID: 12469943