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YKL-05-099

YKL-05-099

  • CAT Number: I013670
  • CAS Number: 1936529-65-5
  • Molecular Formula: C₃₂H₃₄ClN₇O₃
  • Molecular Weight: 600.11
  • Purity: ≥95%
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YKL-05-099 (Cat.No:I013670) is a salt-inducible kinase (SIK) probe; inhibits SIK2 with an IC50 of 40 nM.

Catalog Number I013670
CAS Number 1936529-65-5
Molecular Formula

C₃₂H₃₄ClN₇O₃

Purity 95%
Target Salt-inducible Kinase (SIK)
Solubility DMSO: ≥ 103.33 mg/mL
IUPAC Name 3-(2-chloro-6-methylphenyl)-7-[2-methoxy-4-(1-methylpiperidin-4-yl)anilino]-1-(5-methoxypyridin-2-yl)-4H-pyrimido[4,5-d]pyrimidin-2-one
InChI InChI=1S/C32H34ClN7O3/c1-20-6-5-7-25(33)29(20)39-19-23-17-35-31(37-30(23)40(32(39)41)28-11-9-24(42-3)18-34-28)36-26-10-8-22(16-27(26)43-4)21-12-14-38(2)15-13-21/h5-11,16-18,21H,12-15,19H2,1-4H3,(H,35,36,37)
InChIKey VQINULODWGEVBB-UHFFFAOYSA-N
SMILES CC1=C(C(=CC=C1)Cl)N2CC3=CN=C(N=C3N(C2=O)C4=NC=C(C=C4)OC)NC5=C(C=C(C=C5)C6CCN(CC6)C)OC
Reference

[1]. Sundberg TB, et al. Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo. ACS Chem Biol. 2016 Aug 19;11(8):2105-11.

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