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Yatein

Yatein

  • CAT Number: R014005
  • CAS Number: 40456-50-6
  • Molecular Formula: C22H24O7
  • Molecular Weight: 400.427
  • Purity: 96%
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Yatein(CAS 40456-50-6) is a lignan that has been found in C. formosana and has diverse biological activities. It inhibits the cytochrome P450 (CYP) isoform CYP3A4 (IC50 = 1 μM). Yatein inhibits herpes simplex virus 1 (HSV-1) replication in a plaque reduction assay (IC50 = 30.6 μM). It induces apoptosis and production of reactive oxygen species (ROS) in, and is cytotoxic to, A549 and CL1-5 non-small cell lung cancer (NSCLC) cells (IC50s = 3.5 and 1.9 μM, respectively). Yatein inhibits aggregation of rabbit platelets induced by platelet-activating factor (PAF), collagen, or arachidonic acid.

Catalog Number R014005
CAS Number 40456-50-6
Molecular Formula

C22H24O7

Purity 96
Storage -20°C
IUPAC Name (3R,4R)-4-(1,3-benzodioxol-5-ylmethyl)-3-[(3,4,5-trimethoxyphenyl)methyl]oxolan-2-one
InChI InChI=1S/C22H24O7/c1-24-19-9-14(10-20(25-2)21(19)26-3)7-16-15(11-27-22(16)23)6-13-4-5-17-18(8-13)29-12-28-17/h4-5,8-10,15-16H,6-7,11-12H2,1-3H3/t15-,16+/m0/s1
InChIKey GMLDZDDTZKXJLU-JKSUJKDBSA-N
SMILES COC1=CC(=CC(=C1OC)OC)CC2C(COC2=O)CC3=CC4=C(C=C3)OCO4
Reference

<span style="color:#000000;"><span style="font-size:12px;"><span style="font-family:arial,helvetica,sans-serif;">1.Usia, Tepy, et al. &quot;Potent CYP3A4 Inhibitory Constituents of Piper c ubeba.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">Journal of natural products</i>&nbsp;68.1 (2005): 64-68.<br />
2.Kuo, Yuh-Chi, et al. &quot;Yatein from Chamaecyparis obtusa suppresses herpes simplex virus type 1 replication in HeLa cells by interruption the immediate-early gene expression.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">Antiviral research</i>&nbsp;70.3 (2006): 112-120.<br />
3.Ho, Shang-Tse, et al. &quot;Antitumor agent yatein from Calocedrus formosana Florin leaf induces apoptosis in non-small-cell lung cancer cells.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">Journal of Wood Science</i>&nbsp;65.1 (2019): 1-10.<br />
4.Chen, Jih-Jung, et al. &quot;Anti-platelet aggregation alkaloids and lignans from Hernandia nymphaeifolia.&quot;&nbsp;<i style="font-family: Arial, sans-serif; font-size: 13px;">Planta medica</i>&nbsp;66.03 (2000): 251-256.</span></span></span>

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