Y15

• CAT Number: I003589
• CAS Number: 4506-66-5
• Molecular Formula: C₆H₁₀N₄•4HCl
• Molecular Weight: 284.01
• Purity: ≥95%
• Target: FAK
• Solubility: H2O: ≥ 59 mg/mL
• Storage: Desiccate at RT
• IUPAC Name: benzene-1,2,4,5-tetramine;tetrahydrochloride
• InChI: InChI=1S/C6H10N4.4ClH/c7-3-1-4(8)6(10)2-5(3)9;;;;/h1-2H,7-10H2;4*1H
• InChIKey: BZDGCIJWPWHAOF-UHFFFAOYSA-N
• SMILES: C1=C(C(=CC(=C1N)N)N)N.Cl.Cl.Cl.Cl

Y15 (Cat No.:I003589) is a potent and specific inhibitor of focal adhesion kinase (FAK), which can inhibit its autophosphorylation activity, reduce the viability of cancer cells, and block tumor growth. It can also be used for synthetic material intermediates and intermediates in pharmaceutical research and development and can be used in laboratory research and chemical and pharmaceutical synthesis processes.

Reference

[1]. Hochwald SN, et al. A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer. Cell Cycle. 2009 Aug;8(15):2435-43.
[2]. Zheng D, et al. A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts. Mol Carcinog. 2010 Feb;49(2):200-9.
[3]. Golubovskaya VM, et al. Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide. Mol Cancer Ther. 2013 Feb;12(2):162-72.