XP-59

• CAT Number: I015463
• CAS Number: 890402-73-0
• Molecular Formula: C₁₅H₁₄N₄O₂
• Molecular Weight: 282.3
• Purity: ≥95%

XP-59 (CAT: I015463) is a potent inhibitor of the SARS-CoV main proteinase (Mpro). The Mpro is a key enzyme involved in the formation of the viral replicase/transcriptase complex, making it an attractive target for the development of antiviral drugs. XP-59 demonstrates a high inhibitory potency against the SARS-CoV Mpro, with a Ki (inhibition constant) of 0.1 μM. This suggests that XP-59 has the potential to interfere with viral replication and may serve as a candidate for the development of therapeutic interventions against SARS-CoV infections.

Reference

[1]. Verschueren KH, et al,. A structural view of the inactivation of the SARS coronavirus main proteinase by benzotriazole esters. Chem Biol. 2008 Jun;15(6):597-606.