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XL413 hydrochloride

XL413 hydrochloride

  • CAT Number: I020705
  • CAS Number: 2062200-97-7
  • Molecular Formula: C₁₄H₁₃Cl₂N₃O₂
  • Molecular Weight: 326.18
  • Purity: ≥95%
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XL413 hydrochloride (CAT: I020705) is a potent, selective, and ATP-competitive inhibitor of the cell division cycle 7 (Cdc7) kinase. Cdc7 kinase plays a crucial role in DNA replication and cell cycle progression. By inhibiting Cdc7 kinase, XL413 disrupts DNA replication and cell cycle progression, leading to cell cycle arrest and inhibition of cancer cell growth. XL413 has shown promising anti-cancer activity in preclinical studies and is being investigated as a potential therapeutic option for various types of cancer.

Catalog Number I020705
CAS Number 2062200-97-7
Molecular Formula

C₁₄H₁₃Cl₂N₃O₂

Purity 95%
Reference

[1]. Koltun ES, et al. Discovery of XL413, a potent and selective CDC7 inhibitor. Bioorg Med Chem Lett. 2012 Jun 1;22(11):3727-31.<br>[2]. Sasi NK, et al. The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS One. 2014 Nov 20;9(11):e113300.

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