Xanthohumol

• CAT Number: I004540
• CAS Number: 6754-58-1
• Molecular Formula: C21H22O5
• Molecular Weight: 354.402
• Purity: ≥95%
• Synonyms: (E)-1-[2,4-dihydroxy-6-methoxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
• Target: Autophagy
• Solubility: DMSO: 25 mg/mL
• Storage: Store at +4C
• InChI: InChI=1S/C21H22O5/c1-13(2)4-10-16-18(24)12-19(26-3)20(21(16)25)17(23)11-7-14-5-8-15(22)9-6-14/h4-9,11-12,22,24-25H,10H2,1-3H3/b11-7+
• InChIKey: ORXQGKIUCDPEAJ-YRNVUSSQSA-N
• SMILES: CC(=CCC1=C(C=C(C(=C1O)C(=O)C=CC2=CC=C(C=C2)O)OC)O)C

Xanthohumol (CAT: I004540) is a natural compound found in hops, the flowering cones of the hop plant Humulus lupulus. It belongs to the class of prenylflavonoids and has gained attention for its potential health benefits. Xanthohumol exhibits various pharmacological activities, including antioxidant, anti-inflammatory, anticancer, and antimicrobial properties. It has been studied for its potential role in the prevention and treatment of cancer, cardiovascular diseases, metabolic disorders, and neurodegenerative diseases. Xanthohumol’s antioxidant properties help protect against oxidative stress, while its anti-inflammatory effects contribute to reducing inflammation in the body. Additionally, it has shown promising anticancer activity by inhibiting cell proliferation and inducing apoptosis in cancer cells.

Reference

[1]. Luzak B, et al. Xanthohumol from hop cones (Humulus lupulus L.) prevents ADP-induced platelet reactivity. Arch Physiol Biochem. 2016 Nov 18:1-7.

[2]. Arnaiz-Cot JJ, et al. Xanthohumol modulates calcium signaling in rat ventricular myocytes: Possible Antiarrhythmic properties. J Pharmacol Exp Ther. 2016 Nov 4. pii: jpet.116.236588.

[3]. Gallo C, et al. Hop derived flavonoid xanthohumol inhibits endothelial cell functions via AMPK activation. Oncotarget. 2016 Aug 1.

[4]. Chen PH, et al. The miR-204-3p-targeted IGFBP2 pathway is involved in xanthohumol-induced glioma cell apoptotic death. Neuropharmacology. 2016 Nov;110(Pt A):362-75.

[5]. S?awinska-Brych A, et al. Xanthohumol inhibits the extracellular signal regulated kinase (ERK) signalling pathway and suppresses cell growth of lung adenocarcinoma cells. Toxicology. 2016 May 16;357-358:65-73.