WZ-3146

• CAT Number: I000801
• CAS Number: 1214265-56-1
• Molecular Formula: C24H25ClN6O2
• Molecular Weight: 464.95
• Purity: ≥95%
• Target: EGFR
• Solubility: DMSO ≥90mg/mL Water <1.2mg/mL Ethanol ≥2.8mg/mL
• Storage: 3 years -20℃ powder
• IC50: 2 nM/2 nM (EGFR L858R/E746_A750) [1]
• IUPAC Name: N-[3-[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
• InChI: InChI=1S/C24H25ClN6O2/c1-3-22(32)27-18-5-4-6-20(15-18)33-23-21(25)16-26-24(29-23)28-17-7-9-19(10-8-17)31-13-11-30(2)12-14-31/h3-10,15-16H,1,11-14H2,2H3,(H,27,32)(H,26,28,29)
• InChIKey: APHGZZPEOCCYNO-UHFFFAOYSA-N
• SMILES: CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl

WZ-3146 (Cat.No:I000801) is a promising pharmaceutical compound known for its potential as a targeted therapy in cancer treatment. With its unique mechanism of action, WZ-3146 shows considerable efficacy in inhibiting specific cancer pathways, offering hope for improved patient outcomes in the ongoing battle against cancer.

Reference

[1]. Zhou W, et al. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.Nature. 2009 Dec 24;462(7276):1070-4.