WYC-209

• CAT Number: I019016
• CAS Number: 2131803-90-0
• Molecular Formula: C₂₀H₂₀N₂O₃S
• Molecular Weight: 368.45
• Purity: ≥95%

WYC-209 (CAT: I019016) is a synthetic retinoid and a potent agonist of retinoic acid receptors (RARs). It exhibits pharmacological activity by inducing apoptosis primarily through the caspase 3 pathway. WYC-209 demonstrates significant inhibitory effects on the growth of tumor cells, including malignant murine melanoma TRCs (tumor-repopulating cells), with an IC50 of 0.19 μM. Moreover, WYC-209 has long-term effects with minimal toxicity. In experimental models, WYC-209 has shown the ability to inhibit tumor growth and metastasis, making it a promising candidate for the development of anticancer therapies. In animal studies, WYC-209 administration effectively inhibits tumor metastasis in mice bearing lung metastases. These findings highlight the potential of WYC-209 as a therapeutic agent for the treatment of cancer.

Reference

[1]. Chen J, et al. Inhibition of cancer stem cell like cells by a synthetic retinoid. Nat Commun. 2018 Apr 11;9(1):1406.