Withaferin A

• CAT Number: I011847
• CAS Number: 5119-48-2
• Molecular Formula: C28H38O6
• Molecular Weight: 470.606
• Purity: ≥95%
• Target: NF-κB
• Solubility: Soluble in DMSO > 10 mM
• Storage: -20°C
• IUPAC Name: (1S,2R,6S,7R,9R,11S,12S,15R,16S)-6-hydroxy-15-[(1S)-1-[(2R)-5-(hydroxymethyl)-4-methyl-6-oxo-2,3-dihydropyran-2-yl]ethyl]-2,16-dimethyl-8-oxapentacyclo[9.7.0.02,7.07,9.012,16]octadec-4-en-3-one
• InChI: InChI=1S/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,23-,24+,26+,27-,28+/m0/s1
• InChIKey: DBRXOUCRJQVYJQ-CKNDUULBSA-N
• SMILES: CC1=C(C(=O)OC(C1)C(C)C2CCC3C2(CCC4C3CC5C6(C4(C(=O)C=CC6O)C)O5)C)CO

Withaferin A (CAT: I011847) is a natural bioactive compound derived from the Withania somnifera plant, commonly known as ashwagandha. It is classified as a withanolide and possesses a wide range of pharmacological activities. Withaferin A has been extensively studied for its anticancer properties, exhibiting cytotoxic effects against various cancer cells by inducing apoptosis, inhibiting cell proliferation, and suppressing tumor growth. It also exhibits anti-inflammatory, immunomodulatory, and antioxidant activities. Withaferin A has shown potential therapeutic applications in the treatment of cancer, neurodegenerative diseases, inflammation, and other conditions.

Reference

1: Yan X, Huang G, Liu Q, Zheng J, Chen H, Huang Q, Chen J, Huang H. Withaferin A protects against spinal cord injury by inhibiting apoptosis and inflammation in mice. Pharm Biol. 2017 Dec;55(1):1171-1176. doi: 10.1080/13880209.2017.1288262. PubMed PMID: 28228044.
2: Kakar SS, Parte S, Carter K, Joshua IG, Worth C, Rameshwar P, Ratajczak MZ. Withaferin A (WFA) inhibits tumor growth and metastasis by targeting ovarian cancer stem cells. Oncotarget. 2017 Aug 10;8(43):74494-74505. doi: 10.18632/oncotarget.20170. eCollection 2017 Sep 26. PubMed PMID: 29088802; PubMed Central PMCID: PMC5650357.
3: Kim G, Kim TH, Hwang EH, Chang KT, Hong JJ, Park JH. Withaferin A inhibits the proliferation of gastric cancer cells by inducing G2/M cell cycle arrest and apoptosis. Oncol Lett. 2017 Jul;14(1):416-422. doi: 10.3892/ol.2017.6169. Epub 2017 May 12. PubMed PMID: 28693185; PubMed Central PMCID: PMC5494816.
4: Yu Y, Katiyar SP, Sundar D, Kaul Z, Miyako E, Zhang Z, Kaul SC, Reddel RR, Wadhwa R. Withaferin-A kills cancer cells with and without telomerase: chemical, computational and experimental evidences. Cell Death Dis. 2017 Apr 20;8(4):e2755. doi: 10.1038/cddis.2017.33. PubMed PMID: 28425984; PubMed Central PMCID: PMC5477593.