WHI-P154 - CAS 211555-04-3

WHI-P154 (Cat.No:I002626) is a promising small molecule inhibitor that has gained attention for its potential therapeutic applications. It specifically targets JAK3 and has shown efficacy in preclinical studies for various autoimmune and inflammatory diseases. Further research is ongoing to explore its clinical benefits and safety profile.

Catalog Number: I002626

CAS Number: 211555-04-3

PubChem Substance ID:355039494

Molecular Formula: C₁₆H₁₄BrN₃O₃

Molecular Weight:376.2

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

Synonyms2-bromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol

Property

Molecular Formula: C₁₆H₁₄BrN₃O₃
Molecular Weight376.2
Target:JAK
SolubilityDMSO: ≥ 47 mg/mL
Purity≥95%
Storage3 years -20℃ powder
IC501.8 uM (JAK3); 4 nM(EGFR);100 nM(VEGFR) [1]

Computed Descriptor

IUPAC Name2-bromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol
InChIInChI=1S/C16H14BrN3O3/c1-22-14-6-10-12(7-15(14)23-2)18-8-19-16(10)20-9-3-4-13(21)11(17)5-9/h3-8,21H,1-2H3,(H,18,19,20)
InChIKeyCBIAKDAYHRWZCU-UHFFFAOYSA-N
SMILESCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)O)Br)OC